Evidence map›Paper›PMID 34664407›Full record

ArticleESC heart failure2021

ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction.

Jianqing She, Bowen Lou, Hui Liu, Bo Zhou, Gulinigaer Tuerhong Jiang, Yongbai Luo, Haoyu Wu, Chen Wang, Zuyi Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jianqing SheCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Bowen LouCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Hui LiuBiobank, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Bo ZhouRespiratory Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Gulinigaer Tuerhong JiangCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Yongbai LuoCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Haoyu WuCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Chen WangCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
Zuyi YuanCardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Yanta West 237, Xi'an, 710061, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNMinistry of Education of the People's Republic of China · CNMinistry of Education · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to compare the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) therapy with angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACEI/ARB) therapy for cardiovascular outcomes in patients with acute myocardial infarction (AMI). METHODS AND

resultsData were collected from the Biobank of the First Affiliated Hospital of Xi'an Jiaotong University between January 2016 and December 2020. A total of 7556 AMI patients were screened for eligibility. Propensity score matching based on age, sex, blood pressure, kidney function, baseline left ventricular ejection fraction (LVEF), and cardiovascular medication were conducted, resulting in 291 patients with AMI being assigned to ARNI, ACEI, and ARB group, respectively. Patients receiving ARNI had significantly lower rates of the composite cardiovascular outcome than ACEI {hazard ratio [HR] 0.51, [95% confidence interval (CI), 0.27-0.95], P = 0.02}, and ARB users [HR 0.47, (95%CI, 0.24-0.90), P = 0.02]. Patients receiving ARNI showed lower rates of cardiovascular death than ACEI [HR 0.37, (95%CI, 0.18-0.79), P = 0.01] and ARB users [HR 0.41, (95%CI, 0.18-0.95), P = 0.04]. Subgroup analysis indicated that patients with LVEF no more than 40% tend to benefit more from ARNI as compared with ACEI [HR 0.30, (95%CI, 0.11-0.86), P = 0.01] or ARB [HR 0.21, (95%CI, 0.04-1.1), P = 0.05]. Patients aged no more than 60 years exhibited reduced composite endpoints [HR for ARNI vs. ARB: 0.11, (95%CI, 0.03-0.46), P = 0.002].

conclusionsIn patients with AMI, ARNI was superior to ACEI/ARB in reducing the long-term adverse cardiovascular outcomes. Subgroup analysis further indicates that ARNI is more likely to benefit patients with LVEF less than 40% and aged less than 60 years.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsMyocardial InfarctionHumansMiddle AgedReceptors, AngiotensinStroke VolumeVentricular Function, LeftAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsReceptors, AngiotensinAcute myocardial infarctionAngiotensin converting enzyme inhibitor (ACEI)Angiotensin receptor blockers (ARB)Sacubitril/valsartan (LCZ696)

Identifiers

PMID34664407
PMCPMC8712820
OpenAlexW3205242918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.