SynthesisInteractive cardiovascular and thoracic surgery2022
Male-female differences in acute thoracic aortic dissection: a systematic review and meta-analysis.
Synthesis in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- Sex Differences in Outcomes After Type A Acute Aortic Dissection: An Analysis of the UK National Adult Cardiac Surgery Audit Registry.Journal of cardiovascular development and disease · 2026Article
- Aortic dissection incidence, management, and outcomes: national population-based study.The British journal of surgery · 2026Article
- Sex differences in outcomes of a two-stage approach to aortic arch surgery: 8-year experience of a national aortovascular centre.Journal of cardiothoracic surgery · 2026Article
- Sex-Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD.Journal of the American Heart Association · 2026Article
- Is TEVAR the best method for thoracic aortic pathologies?Heart and vessels · 2026Article
- Predictive value of initial triage vital signs for in-hospital mortality in acute aortic dissection patients: a retrospective study in the emergency department.Frontiers in medicine · 2026Article
- Sex-Based Differences in Dissection Patterns and Surgical Strategies in Tear-Oriented Repair for Acute Type A Aortic Dissection.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
- Sex-Based Differences in Dissection Patterns and Surgical Strategies in Tear-Oriented Repair for Acute Type A Aortic Dissection: A Single-Center Retrospective Study.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
- Presentation, management, and clinical outcomes of acute type A dissection: Does sex matter?JTCVS open · 2025Article
- Association of neutrophil to high density lipoprotein cholesterol ratio with aortic dissection and aneurysm risk: epidemiological insights from prospective cohort study based on UK biobank.BMC public health · 2025Article
- Sex differences in hospital outcomes of medically-managed type B aortic dissection.Frontiers in cardiovascular medicine · 2025Article
- The association between sex and outcomes after thoracic endovascular repair for acute type B aortic dissection.Journal of vascular surgery · 2024Article
- Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Operative Mortality After Type A Aortic Dissection Surgery: Differences Based on Sex and Age.JACC. Advances · 2024Article
- Male-Female Differences in Acute Type B Aortic Dissection.Journal of the American Heart Association · 2024Article
- Sex differences in long-term outcomes following surgery for acute type A aortic dissection: a systematic review and meta-analysis.Annals of cardiothoracic surgery · 2023Article
- Risk Factors for Thoracic Aortic Dissection.Genes · 2022Review
- More insights into acute aortic dissection, but with what clinical consequence?Interactive cardiovascular and thoracic surgery · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study aims to systematically review published literature on male-female differences in presentation, management and outcomes in patients diagnosed with acute thoracic aortic dissection (AD).
methodsA systematic literature search was conducted for studies published between 1 January 1999 and 19 October 2020 investigating mortality and morbidity in adult patients diagnosed with AD. Patient and treatment characteristics were compared with odds ratios (ORs) and standardized mean differences and a meta-analysis using a random-effects model was performed for early mortality. Overall survival and reoperation were visualized by pooled Kaplan-Meier curves.
resultsNine studies investigating type A dissections (AD-A), 1 investigating type B dissections (AD-B) and 3 investigating both AD-A and AD-B were included encompassing 18 659 patients. Males were younger in both AD-A (P < 0.001) and AD-B (P < 0.001), and in AD-A patients males had more distally extended dissections [OR 0.57, 95% confidence interval (CI) 0.46-0.70; P < 0.001]. Longer operation times were observed for males in AD-A (standardized mean difference 0.29, 95% CI 0.17-0.41; P < 0.001) while male patients were less often treated conservatively in AD-B (OR 0.65, 95% CI 0.58-0.72; P < 0.001). The pooled early mortality risk ratio for males versus females was 0.94 (95% CI 0.84-1.06, P = 0.308) in AD-A and 0.92 (95% CI 0.83-1.03, P = 0.143) in AD-B. Pooled overall mortality in AD-A showed no male-female difference, whereas male patients had more reinterventions during follow-up.
conclusionsThis systematic review shows male-female differences in AD patient and treatment characteristics, comparable early and overall mortality and inconsistent outcome reporting. As published literature is scarce and heterogeneous, large prospective studies with standardized reporting of male-female characteristics and outcomes are clearly warranted. Improved knowledge of male-female differences in AD will help shape optimal individualized care for both males and females. CLINICAL REGISTRATION NUMBER: PROSPERO, ID number: CRD42020155926.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.