Evidence map›Paper›PMID 34663913›Full record

ArticleCommunications biology2021

Probiotic consumption influences universal adaptive mutations in indigenous human and mouse gut microbiota.

Chenchen Ma, Chengcheng Zhang, Denghui Chen, Shuaiming Jiang, Siyuan Shen, Dongxue Huo, Shi Huang, Qixiao Zhai, Jiachao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Distinct Effects ofMicroorganisms · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Effects of Probiotics on Gut Microbiota: An Overview.International journal of molecular sciences · 2024
    Review
  12. Article
  13. Intrahost evolution of the gut microbiota.Nature reviews. Microbiology · 2023
    Review
  14. Vitamin BMicrobiome · 2023
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Chenchen Ma *College of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, 570228, Haikou, China.
Chengcheng Zhang *State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 214122, Wuxi, China.
Denghui Chen *Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Shuaiming JiangCollege of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, 570228, Haikou, China.
Siyuan ShenCollege of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, 570228, Haikou, China.
Dongxue HuoCollege of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, 570228, Haikou, China.
Shi HuangDepartment of Pediatrics and Center for Microbiome Innovation at Jacobs School of Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. shihuang047@gmail.com.ORCID 0000-0002-7529-2269
Qixiao ZhaiState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 214122, Wuxi, China. zhaiqixiao@sina.com.ORCID 0000-0002-0605-2675
Jiachao ZhangCollege of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, 570228, Haikou, China. zhjch321123@163.com.ORCID 0000-0001-8099-6749
Hainan University · CNJiangnan University · CNUniversity of California San Diego · US

Funding

Hainan Provincial Department of Science and Technology (Department of Science and Technology of Hainan Province) 320RC513
6 · The paper itself

Abstract

The adaptive evolution in indigenous intestinal microbes derived from probiotics is critical to safety and efficacy evaluation of probiotics, yet it is still largely underexplored. Here, through 11 publicly accessible datasets, we demonstrated that probiotic consumption can lead to widespread single-nucleotide variants (SNVs) in the native microbiota. Interestingly, the same probiotic strains introduced far more SNVs in mouse gut than humans. Furthermore, the pattern of probiotics-induced SNVs was highly probiotic-strain specific, and 17 common SNVs in Faecalibacterium prausnitzii genome were identified cross studies, which might lead to changes in bacterial protein structure. Further, nearly 50% of F. prausnitzii SNVs can be inherited for six months in an independent human cohort, whereas the other half only transiently occurred. Collectively, our study substantially extended our understanding of co-evolution of the probiotics and the indigenous gut microbiota, highlighting the importance of assessment of probiotics efficacy and safety in an integrated manner.

Indexed as

Adaptation, BiologicalMutationAnimalsBacteriaFemaleGastrointestinal MicrobiomeHumansMaleMiceProbiotics

Identifiers

PMID34663913
PMCPMC8523657
OpenAlexW3206431014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.