Evidence map›Paper›PMID 34663908›Full record

ArticleCell death and differentiation2022

MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling.

Shan Xin, Constanze Mueller, Susanne Pfeiffer, Vanessa A N Kraft, Juliane Merl-Pham, Xuanwen Bao, Regina Feederle, Xiang Jin, Stefanie M Hauck, Philippe Schmitt-Kopplin and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 78 citations in OpenAlex.

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  18. Translational lung cancer research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Shan Xin *Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4735-0935
Constanze Mueller *Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Susanne Pfeiffer *Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Vanessa A N KraftGenetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4432-7852
Juliane Merl-PhamResearch Unit Protein Science, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3422-4083
Xuanwen BaoDepartment of Medical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Zhejiang, China.
Regina FeederleMonoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3981-367X
Xiang JinMinistry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, 571158, Haikou, China.
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-1630-6827
Philippe Schmitt-KopplinResearch Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Joel A SchickGenetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany. joel.schick@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-8623-4910
Helmholtz Zentrum München · DEHainan Normal University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that promote oxidation within the lipid compartment. Calcium (Ca

Indexed as

Biochemical PhenomenaFerroptosisCalciumLipid PeroxidationOxidation-ReductionPhospholipidsCalciumPhospholipids

Identifiers

PMID34663908
PMCPMC8901757
OpenAlexW3205635146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.