Evidence map›Paper›PMID 34663904›Full record

ArticleMolecular psychiatry2021

Modifying the m

Braulio Martinez De La Cruz, Robert Markus, Sunir Malla, Maria Isabel Haig, Chris Gell, Fei Sang, Eleanor Bellows, Mahmoud Awad Sherif, Denise McLean, Anbarasu Lourdusamy and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. mNature reviews. Neuroscience · 2026
    Review
  3. Review
  4. Integrated genetic analysis reveals synaptic mFrontiers in molecular neuroscience · 2026
    Article
  5. mEpigenomes · 2025
    Review
  6. Article
  7. Review
  8. N6-methyladenosine methylation: a novel key to unlocking mental disorders.The international journal of neuropsychopharmacology · 2025
    Review
  9. Article
  10. Global Co-regulatory Cross Talk Between mMolecular neurobiology · 2025
    Article
  11. Article
  12. Review
  13. Effects of mFrontiers in aging neuroscience · 2025
    Article
  14. Article
  15. RNA methylation in neurodevelopment and related diseases.Acta biochimica et biophysica Sinica · 2024
    Review
  16. Article
  17. Insights into the mCell & bioscience · 2024
    Review
  18. Article
  19. FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via mProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Braulio Martinez De La CruzDivision of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
Robert MarkusSchool of Life Sciences Imaging Facility, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0003-4535-303X
Sunir MallaDeep Seq: Next Generation Sequencing Facility, University of Nottingham, Nottingham, UK.
Maria Isabel HaigDivision of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
Chris GellSchool of Life Sciences Imaging Facility, University of Nottingham, Nottingham, UK.
Fei SangDeep Seq: Next Generation Sequencing Facility, University of Nottingham, Nottingham, UK.
Eleanor BellowsDivision of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
Mahmoud Awad SherifDivision of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
Denise McLeanSchool of Life Sciences Imaging Facility, University of Nottingham, Nottingham, UK.
Anbarasu LourdusamyChildren's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1978-6301
Tim SelfSchool of Life Sciences Imaging Facility, University of Nottingham, Nottingham, UK.
Zsuzsanna BodiDivision of Plant Sciences, School of Biosciences, University of Nottingham, Nottingham, UK.
Stuart SmithChildren's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Michael FayNanoscale and Microscale Research Centre, University of Nottingham, Nottingham, UK.
Ian A MacdonaldDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.
Rupert FrayDivision of Plant Sciences, School of Biosciences, University of Nottingham, Nottingham, UK.
Helen Miranda KnightDivision of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK. Helen.knight@nottingham.ac.uk.ORCID http://orcid.org/0000-0003-3267-9591
University of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L013827/1
6 · The paper itself

Abstract

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated, and which transcripts are silenced or processed as part of the tagging process is still unknown. Modification of RNA by N6-methyladenosine (m

Indexed as

EpigenomeSynapsesAlkB Homolog 5, RNA DemethylaseBrainDemethylationHumansNeuronal PlasticityALKBH5 protein, humanAlkB Homolog 5, RNA Demethylase

Identifiers

PMID34663904
PMCPMC8872986
OpenAlexW3206854512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.