ArticleScientific reports2021
A small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- That Stinging Sensation: Modularity and the Origin of the Stinging Cell.Integrative and comparative biology · 2025Review
- Piezo proteins, mechano reception and behaviour in Hydra.Scientific reports · 2025Article
- Linking Research Data with Physically Preserved Research Materials in Chemistry.Scientific data · 2025Article
- A predatory gastrula leads to symbiosis-independent settlement in Aiptasia.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
8 authors.
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Abstract
Cnidarians are characterized by the possession of stinging organelles, called nematocysts, which they use for prey capture and defense. Nematocyst discharge is controlled by a mechanosensory apparatus with analogies to vertebrate hair cells. Members of the transient receptor potential (TRPN) ion channel family are supposed to be involved in the transduction of the mechanical stimulus. A small molecule screen was performed to identify compounds that affect nematocyst discharge in Hydra. We identified several [2.2]paracyclophanes that cause inhibition of nematocyst discharge in the low micro-molar range. Further structure-activity analyses within the compound class of [2.2]paracyclophanes showed common features that are required for the inhibitory activity of the [2.2]paracyclophane core motif. This study demonstrates that Hydra can serve as a model for small molecule screens targeting the mechanosensory apparatus in native tissues.
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