Evidence map›Paper›PMID 34663876›Full record

ArticleScientific reports2021

Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice.

Paulina M Getsy, Sripriya Sundararajan, Walter J May, Graham C von Schill, Dylan K McLaughlin, Lisa A Palmer, Stephen J Lewis

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Paulina M GetsyDepartment of Pediatrics, Case Western Reserve University, Biomedical Research Building BRB 319, 10900 Euclid Avenue Mail Stop 1714, Cleveland, OH, 44106-1714, USA.
Sripriya SundararajanPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Walter J MayPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Graham C von SchillPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Dylan K McLaughlinPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Lisa A PalmerPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Stephen J LewisDepartment of Pediatrics, Case Western Reserve University, Biomedical Research Building BRB 319, 10900 Euclid Avenue Mail Stop 1714, Cleveland, OH, 44106-1714, USA. sjl78@case.edu.
University of Virginia · USCase Western Reserve University · USUniversity of Maryland, Baltimore · US

Funding

S-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7M
NHLBI NIH HHS P01 HL101871
6 · The paper itself

Abstract

The roles of endothelial nitric oxide synthase (eNOS) in the ventilatory responses during and after a hypercapnic gas challenge (HCC, 5% CO

Indexed as

AnimalsFemaleHypercapniaHypoxiaMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIIPulmonary VentilationRespirationRespiratory InsufficiencyTidal VolumeNitric Oxide Synthase Type IIINos3 protein, mouse

Identifiers

PMID34663876
PMCPMC8523677
OpenAlexW3206077300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.