Evidence map›Paper›PMID 34663875›Full record

ArticleScientific reports2021

Ventricular arrhythmias in mouse models of diabetic kidney disease.

Kenneth R Laurita, Shenaz Khan, Tracy McMahon, Adrienne T Dennis, Vincent Li, Robert Gaivin, Hima Sapa, Ji-Dong Fu, Jeffrey R Schelling

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kenneth R LauritaDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA. Kenneth.Laurita@case.edu.
Shenaz KhanDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Tracy McMahonDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Adrienne T DennisDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Vincent LiDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Robert GaivinDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Hima SapaDepartment of Medicine, University Hospitals Cleveland, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ji-Dong FuDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
Jeffrey R SchellingDepartment of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.
MetroHealth Medical Center · USCase Western Reserve University · USUniversity Hospitals of Cleveland · US

Funding

Biophysical Modulation of Cardiac Ion Channels by MicroRNAR01HL139006 · NHLBI · OHIO STATE UNIVERSITY · PI Isabelle Deschenes, Jidong Fu · 2017 to 2026
$5.1M
Novel mechanisms and treatment of arrhythmia during resuscitationR01HL142754 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI KENNETH LAURITA, Lance D Wilson · 2020 to 2026
$3.4M
Optically guided catheter ablation of atrial fibrillationR01HL149369 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI HENDON, CHRISTINE P, LAURITA, KENNETH · 2019 to 2022
$2.8M
NHLBI NIH HHS R01 HL139006NHLBI NIH HHS R01 HL142754NHLBI NIH HHS R01 HL149369NIH HHS DK106965NIH HHS HL123012NIH HHS HL139006
6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects more than 20 million people in the US, and it is associated with a significantly increased risk of sudden cardiac death (SCD). Despite the significance, the mechanistic relationship between SCD and CKD is not clear and there are few effective therapies. Using optical mapping techniques, we tested the hypothesis that mouse models of progressive diabetic kidney disease (DKD) exhibit enhanced ventricular arrhythmia incidence and underlying arrhythmia substrates. Compared to wild-type mice, both Lepr

Indexed as

Action PotentialsAnimalsArrhythmias, CardiacDiabetes ComplicationsDiabetes MellitusDiabetic NephropathiesDisease Models, AnimalHeart RateMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacTachycardia, VentricularVoltage-Sensitive Dye Imaging

Identifiers

PMID34663875
PMCPMC8523538
OpenAlexW3206494527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.