Evidence map›Paper›PMID 34663830›Full record

ArticleScientific reports2021

Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway.

Rakshya Gorkhali, Li Tian, Bin Dong, Pritha Bagchi, Xiaonan Deng, Shrikant Pawar, Duc Duong, Ning Fang, Nicholas Seyfried, Jenny Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling.Chronic diseases and translational medicine · 2024
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rakshya GorkhaliDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Li TianDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Bin DongDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Pritha BagchiEmory Integrated Proteomics Core, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Xiaonan DengDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Shrikant PawarDepartment of Biology, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Duc DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Ning FangDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA.
Nicholas SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Jenny YangDepartment of Chemistry, Center of Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA, 30303, USA. jenny@gsu.edu.
Georgia State University · USEmory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-protein-coupled receptors (GPCRs) are a target for over 34% of current drugs. The calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca

Indexed as

AnimalsCalciumCalcium SignalingCell MembraneChlorocebus aethiopsCOS CellsEndocytosisEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPHEK293 CellsHumansIntracellular Calcium-Sensing ProteinsProtein TransportReceptors, Calcium-SensingVesicular Transport ProteinsCalciumEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanIntracellular Calcium-Sensing ProteinsReceptors, Calcium-SensingVAPA protein, humanVesicular Transport Proteins

Identifiers

PMID34663830
PMCPMC8523568
OpenAlexW3207892472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.