ArticleTranslational psychiatry2021
Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- "The wrong tools for the right job": a critical meta-analysis of traditional tests to assess behavioural impacts of maternal separation.Psychopharmacology · 2023Pooled it
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.Molecular autism · 2026Article
- In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses.The FEBS journal · 2025Article
- Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAMolecular psychiatry · 2025Article
- Identifying Tipping Points during Healthy Brain Aging through Single-Nucleus Transcriptomic Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regional and aging-specific cellular architecture of non-human primate brains.Genome medicine · 2025Article
- Perturbations in the microbiota-gut-brain axis shaped by social status loss.Communications biology · 2025Article
- Prelimbic cortex is involved in the regulation of morphine-induced conditioned place preference in both resistant and sensitive mice.Scientific reports · 2025Article
- Sex-Dependent Modulation of AMPA and GABACurrent neuropharmacology · 2025Article
- Emotional neglect in childhood modulates aperiodic offset in the left pars orbitalis in adulthood.Frontiers in neuroscience · 2025Article
- GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function.Molecular psychiatry · 2024Article
- Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.Scientific reports · 2024Article
- Clinical Correlation of Altered Molecular Signatures in Epileptic Human Hippocampus and Amygdala.Molecular neurobiology · 2024Article
- Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms.Animal models and experimental medicine · 2023Review
- Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.Science advances · 2023Article
- Growth Hormone Action in Somatostatin Neurons Regulates Anxiety and Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus.Molecular brain · 2023Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders. GABAergic microcircuits in the amygdala are critically implicated in anxiety; however, whether their function is altered after ELS is not known. Here we identify a novel mechanism by which kainate receptors (KARs) modulate feedforward inhibition in the lateral amygdala (LA) and show that this mechanism is downregulated after ELS induced by maternal separation (MS). Specifically, we show that in control rats but not after MS, endogenous activity of GluK1 subunit containing KARs disinhibit LA principal neurons during activation of cortical afferents. GluK1 antagonism attenuated excitability of parvalbumin (PV)-expressing interneurons, resulting in loss of PV-dependent inhibitory control and an increase in firing of somatostatin-expressing interneurons. Inactivation of Grik1 expression locally in the adult amygdala reduced ongoing GABAergic transmission and was sufficient to produce a mild anxiety-like behavioral phenotype. Interestingly, MS and GluK1-dependent phenotypes showed similar gender specificity, being detectable in male but not female rodents. Our data identify a novel KAR-dependent mechanism for cell-type and projection-specific functional modulation of the LA GABAergic microcircuit and suggest that the loss of GluK1 KAR function contributes to anxiogenesis after ELS.
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