Evidence map›Paper›PMID 34663731›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The genetic source tracking of human urinary exosomes.

Qingfu Zhu, Liming Cheng, Chunyu Deng, Liu Huang, Jiaoyuan Li, Yong Wang, Meng Li, Qinsi Yang, Xianjun Dong, Jianzhong Su and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
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  8. Review
  9. Isolating Astrocyte-Derived Extracellular Vesicles From Urine.International journal of nanomedicine · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Qingfu ZhuEye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China.
Liming ChengDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0001-6444-5090
Chunyu DengSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Liu HuangDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiaoyuan LiDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yong WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Meng LiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Qinsi YangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Xianjun DongGenomics and Bioinformatics Hub, Precision Neurology Program, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-8052-9320
Jianzhong SuEye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0003-1054-6042
Luke P LeeRenal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; lplee@bwh.harvard.edu feiliu@wmu.edu.cn.ORCID 0000-0002-1436-4054
Fei LiuEye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China; lplee@bwh.harvard.edu feiliu@wmu.edu.cn.ORCID 0000-0001-5259-5753
Tongji Hospital · CNUniversity of Chinese Academy of Sciences · CNWenzhou Medical University · CNBrigham and Women's Hospital · USHarbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.

Indexed as

UrineExosomesHumansLiquid BiopsyNeoplasmsbiomarker discoverycancer diagnosisexosome originRNA sequencing

Identifiers

PMID34663731
PMCPMC8639375
OpenAlexW3206847211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.