ArticleLearning & memory (Cold Spring Harbor, N.Y.)2021
Distributed learning episodes create a context fear memory outside the hippocampus that depends on perirhinal and anterior cingulate cortices.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 27 citations in OpenAlex.
- Evidence of allocentric spatial learning in male rats with large lesions of the hippocampus.PloS one · 2026Article
- Effects of maternal social isolation on adult rodent offspring cognition.Scientific reports · 2023Article
- Chronic gut inflammation impairs contextual control of fear.Scientific reports · 2022Article
- Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats.Frontiers in behavioral neuroscience · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Damage to the hippocampus (HPC) typically causes retrograde amnesia for contextual fear conditioning. Repeating the conditioning over several sessions, however, can eliminate the retrograde amnesic effects. This form of reinstatement thus permits modifications to networks that can support context memory retrieval in the absence of the HPC. The present study aims to identify cortical regions that support the nonHPC context memory. Specifically, the contribution of the perirhinal cortex (PRH) and the anterior cingulate cortex (ACC) were examined because of their established importance to context memory. The findings show that context memories established through distributed reinstatement survive damage limited only to the HPC, PRH, or ACC. Combined lesions of the HPC and PRH, as well as the HPC and ACC, caused retrograde amnesia, suggesting that network modifications in the PRH and ACC enable context fear memories to become resistant to HPC damage.
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