Evidence map›Paper›PMID 34663676›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2022

Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity.

Jessica I Griffith, Minjee Kim, Daniel J Bruce, Cristina D Peterson, Kelley F Kitto, Afroz S Mohammad, Sneha Rathi, Carolyn A Fairbanks, George L Wilcox, William F Elmquist

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jessica I GriffithBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota grif0285@umn.edu elmqu011@umn.edu.
Minjee KimBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Daniel J BruceBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Cristina D PetersonBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Kelley F KittoBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Afroz S MohammadBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Sneha RathiBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
Carolyn A FairbanksBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
George L WilcoxBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota.
William F ElmquistBrain Barriers Research Center (J.I.G., M.K., A.S.M., S.R., W.F.E.), Department of Pharmaceutics (J.I.G., M.K., A.S.M., S.R., C.A.F., W.F.E.), Department of Pharmacology (D.J.B., C.A.F., G.L.W.), Department of Neuroscience (C.D.P., K.F.K., C.A.F., G.L.W.), and Department of Dermatology (G.L.W.), University of Minnesota, Minneapolis Elmquist Laboratory, Minneapolis, Minnesota grif0285@umn.edu elmqu011@umn.edu.
University of Minnesota · US

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
Mechanisms of Opioid Receptor InteractionsR01DA015438 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WILCOX, GEORGE LATIMER · 2004 to 2014
$3.3M
NIDA NIH HHS R01 DA015438NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

Novel combinations of specific opioid agonists like loperamide and oxymorphindole targeting the

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Central Nervous SystemDrug CombinationsDrug SynergismFemaleGenotypeLoperamideMaleMiceMice, Inbred ICRMorpholinesReceptors, OpioidTissue DistributionAbcg2 protein, mouseATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Drug CombinationsLoperamideMorpholinesoxymorphindoleReceptors, Opioid

Identifiers

PMID34663676
PMCPMC8969136
OpenAlexW3205037947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.