ArticleAnnals of the rheumatic diseases2021
Mechanosensitive TRPV4 is required for crystal-induced inflammation.
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Article in Annals of the rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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55citing papers in PubMed, 1 pooled it
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Role of NLRP3 in the pathogenesis and treatment of gout arthritis.Frontiers in immunology · 2023Pooled it
- Network Pharmacology and Experimental Validation Reveal Wu Miao Pill's Therapeutic Effects on Acute Gouty Arthritis Through P2X7R Regulation.Biochemical genetics · 2026Article
- Nanomedicine targeting ECM stiffness: restoring mechanical homeostasis for cancer immunotherapy.Materials today. Bio · 2026Review
- Exercise-primed Trpv4+ progenitors sense mechanical to regulate graded transition in enthesis regeneration.Bone & joint research · 2026Article
- Cascade Nanozyme-Catalyzed Tophi Dissolution and ROS Scavenging for Anti-Inflammatory Therapy in Gouty Arthritis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout.Neuroscience bulletin · 2026Article
- Cutaneous TRPV4 Potentiates the Afferent Transmission of Electroacupuncture Stimulation.ACS omega · 2026Article
- Engineering technology of implantable galvanic cells for silencing the bone-neural axis in gouty arthritis therapy.Nature communications · 2026Article
- Mechanisms of monosodium urate crystal-induced bone destruction in gouty arthritis (Review).Biomedical reports · 2026Review
- Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy.Clinical and translational medicine · 2026Article
- Interaction between transient receptor potential vanilloid 4 and glutamate NMDA receptor subunit 1 mediates endoplasmic reticulum stress and neuroinflammation in postoperative delirium.Molecular biomedicine · 2026Article
- Pentagalloyl glucose Suppresses MSU Crystal-Induced Gout Inflammation and Arachidonic Acid Production In Vitro and In Vivo.Research square · 2026Article
- Synovial immune control failure in osteoarthritis: from maintenance of tissue homeostasis to inflammatory niche formation.Frontiers in immunology · 2026Review
- Potential role of theFrontiers in genetics · 2026Article
- LncSLED1 inhibits monosodium urate-induced macrophage inflammation by promoting Cosmc methylation to upregulate CA72-4.Central-European journal of immunology · 2026Article
- The Mechanosensation-Metabolism-Inflammation Axis: The Central Role of Piezo1 and TRPV4 in Hypertension-Related Atherosclerosis.International journal of general medicine · 2026Review
- Pentagalloyl glucose suppresses MSU crystal-induced gout inflammation and arachidonic acid productionFrontiers in pharmacology · 2026Article
- The "Mechano-Metabolic-Immune" crosstalk within the skeletal muscle microenvironment: evolution of homeostatic remodeling and quality control mechanisms.Frontiers in immunology · 2026Review
- Dual Mechanisms of Naru Sanwei Pills in Gout: NLRP3 Inflammasome Inhibition and Uric Acid Regulation.Journal of inflammation research · 2026Article
- DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage.Molecular neurobiology · 2025Article
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Authors and funding
20 authors at 4 institutions in 2 countries.
Zhou Lan *Department of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Lvyi Chen *Department of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA clyhappy05@163.com hongzhen.hu@wustl.edu.ORCID 0000-0002-4318-3033
Jing FengDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Zili XieDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Zhiyong LiuRenmin Hospital of Wuhan University, Wuhan, Hubei, China.
Fang WangCenter for the Study of Itch and Sensory Disorders, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Peng LiuSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei, People's Republic of China.
Xueping YueDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Lixia DuDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.ORCID 0000-0002-8578-8268
Yonghui ZhaoDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Pu YangDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Jialie LuoDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Zhe ZhuHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Xueming HuDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Liang CaoDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Ping LuDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Rajan SahDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Kory LavineDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Brian KimDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
Hongzhen HuDepartment of Anesthesiology, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA clyhappy05@163.com hongzhen.hu@wustl.edu.
Washington University in St. Louis · USSouth Central Minzu University · CNColumbia University Irving Medical Center · USWuhan University · CN
Funding
TARGETING THE TRANSIENT RECEPTOR POTENTIAL CHANNELS TO IMPROVE BOWEL DYSFUNCTIONR01DK103901 · NIDDK · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2015 to 2023
$3.4MDeciphering the Piezo2-Merkel cell signaling mechanisms in itchR01AR077183 · NIAMS · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2020 to 2024
$2.6MMECHANISMS OF TRPV4-MEDIATED NEUROPATHIC PAINR01AA027065 · NIAAA · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2018 to 2022
$2.5MNIAAA NIH HHS R01 AA027065NIAMS NIH HHS R01 AR077183NIDDK NIH HHS R01 DK103901
Abstract
Crystal structures activate innate immune cells, especially macrophages and initiate inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 channel in crystal-induced inflammation. Real-time RT-PCR, RNAscope in situ hybridisation, and
Indexed as
AdultAnimalsArthralgiaArthritisArthritis, GoutyCrystal ArthropathiesGoutHumansInflammasomesInflammationInterleukin-1betaLeukocytes, MononuclearMacrophagesMaleMiceMiddle AgedInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinTRPV1 protein, mouseTRPV4 protein, humanTrpv4 protein, mouseTRPV Cation ChannelsUric Acidarthritiscytokinesexperimentalgoutimmune system diseases
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