Evidence map›Paper›PMID 34663467›Full record

ArticleMilitary Medical Research2021

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling.

Xi-Yao Chen, Yang Jiao, Fu-Yang Zhang

Open access · diamondAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Military Medical Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xi-Yao ChenDepartment of Geriatrics, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
Yang JiaoDepartment of Stomatology, The 7th Medical Center of Chinese, PLA General Hospital, Beijing, 100700, China.
Fu-Yang ZhangDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China. plazhangfuyang@163.com.
Xijing Hospital · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

Indexed as

FenofibrateHeart DiseasesHumansPPAR alphaTemperatureFenofibratePPAR alphaCardiac dysfunctionFatty acid metabolismLow ambient temperaturePeroxisome proliferator-activated receptor-αRemodeling

Identifiers

PMID34663467
PMCPMC8524846
OpenAlexW3206568436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.