ArticleJournal of orthopaedic surgery and research2021
Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- The Impact of Abduction Orthoses for the Treatment of Hip Dysplasia on the Development of Motor Skills: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Association of hip dysplasia in newborns with ethnicity using graf method ultrasound.Pakistan journal of medical sciences · 2025Article
- Risk factors for residual acetabular dysplasia after closed reduction treatment of developmental dysplasia of the hip: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Review
- Risk Factors for Developmental Dysplasia of the Hip: A Critical Analysis About an Unclear Relationship.Journal of clinical medicine · 2024Article
- Is Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?Journal of clinical medicine · 2024Article
- Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?Frontiers in physiology · 2023Review
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH.
methodsWe identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score.
resultsThe mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found.
conclusionAs a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH. LEVEL OF EVIDENCE: Level 2, Prospective comparative study.
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