Evidence map›Paper›PMID 34663389›Full record

Observational studyInternational breastfeeding journal2021

Does breastfeeding protect children from COVID-19? An observational study from pediatric services in Majorca, Spain.

Sergio Verd, Jan Ramakers, Isabel Vinuela, Maria-Isabel Martin-Delgado, Aina Prohens, Ruth Díez

Abstract readObservational Study
In one paragraph

Observational study in International breastfeeding journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
  7. A Preliminary Study on Acute Otitis Media in Spanish Children with Late Dinner Habits.International journal of environmental research and public health · 2022
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sergio VerdPediatric Unit. La Vileta Surgery. Department of Primary Care, Matamusinos Street, 07013, Palma de Mallorca, Spain. drsverd@gmail.com.ORCID 0000-0002-2612-0794
Jan RamakersDepartment of Pediatrics, Son Espases University Hospital, 79 Valldemossa Road, 07120, Palma de Mallorca, Spain.
Isabel VinuelaDepartment of Pediatrics, Son Espases University Hospital, 79 Valldemossa Road, 07120, Palma de Mallorca, Spain.
Maria-Isabel Martin-DelgadoPediatric Unit. Santa Ponsa Surgery. Department of Primary Care, Riu Sil Street, 07180, Calvia, Mallorca, Spain.
Aina ProhensDepartment of Pediatrics, Son Llatzer University Hospital, Manacor Road, 07120 07198, Palma de Mallorca, Spain.
Ruth DíezDepartment of Pediatrics, Son Espases University Hospital, 79 Valldemossa Road, 07120, Palma de Mallorca, Spain.

Funding

idisba Baleares Medical Research Institute
6 · The paper itself

Abstract

backgroundIt has been demonstrated that children who had been breastfed remain better protected against various infections, and notably respiratory tract infections, well beyond infancy. Since the role of breastfeeding to explain why children are less affected by COVID-19 has not been studied until now, the aim of this study was to determine whether any history of breastfeeding reduces the incidence rate of COVID-19 in children.

methodsThis was a secondary analysis of an observational study on clinical and epidemiological characteristics of pediatric COVID-19 in Majorca. A total of 691 children were recruited during the 5 months of August-December 2020. Eligible participants were children under 14 who were tested for SARS-CoV-2 in pediatric emergency services. The independent explanatory variable was any breastfeeding. Bivariate analyses were conducted through the Chi-square test, the Fisher's Exact test or the Student's T test. All children had the same demographic, epidemiological and clinical data collected through a study team member interview and via the participants medical records.

resultsWithin the sample of children who visited emergency services with symptoms of potential COVID-19, we found higher prevalence of positive SARS-CoV-2 RT-PCR test results among those who were exclusively formula fed compared with those who were ever breastfed (OR 2.48; 95% CI 1.45, 3.51; P = 0.036).

conclusionsThe present study suggests that ever breastfeeding reduces the risk of COVID-19 among children, as documented for other infections.

Indexed as

Breast FeedingCOVID-19ChildFemaleHumansSARS-CoV-2SpainBreastfeedingChildCOVID-19Disease transmissionImmune responsesOxidative stressSymptoms

Identifiers

PMID34663389
PMCPMC8521512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.