ArticleJournal of orthopaedic surgery and research2021
Association of total testosterone status with bone mineral density in adults aged 40-60 years.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Low Testosterone Level and Risk of Adverse Clinical Events among Male Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Cohort Studies.Journal of healthcare engineering · 2022Pooled it
- Testosterone Replacement Therapy Is Associated With Increased Incidence Rate of Vertebral Fractures: A Matched Retrospective Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Inverted U-shaped association between total testosterone with bone mineral density in men over 60 years old.BMC endocrine disorders · 2024Article
- Predictive power of lipid-related indicators for testosterone deficiency: a comparative analysis, NHANES 2011-2016.International urology and nephrology · 2024Observational
- Effects of Testosterone in Mediating the Relationship Between Daytime Napping and Osteoporosis in European Populations: A Mendelian Randomization Study.Calcified tissue international · 2024Article
- The effect of testosterone level on metabolic syndrome: a cross-sectional study.Hormones (Athens, Greece) · 2024Article
- Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes.Korean journal of orthodontics · 2023Article
- Mendelian randomization analyses of associations between breast cancer and bone mineral density.Scientific reports · 2023Article
- Association between testosterone levels and bone mineral density in females aged 40-60 years from NHANES 2011-2016.Scientific reports · 2022Article
- Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study.PloS one · 2022Article
- Association of Sex Hormones and Sex Hormone-Binding Globulin Levels With Bone Mineral Density in Adolescents Aged 12-19 Years.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvidence linking total testosterone and bone mineral density (BMD) in adults is very limited. According to our review of the literature, only a few reports have focused on the relationship between total testosterone and bone mineral density in adults. Therefore, the purpose of this study was to determine the relationship between total testosterone and total bone mineral density in adults aged 40-60 years.
methodsWe used a cross-sectional study of a non-institutionalized U.S. population sample from the National Health and Nutrition Examination Survey. A weighted multivariate linear regression model was used to evaluate the relationship between total testosterone and total bone mineral density. Subgroup analyses were further performed.
resultsIn multiple regression models adjusted for potential confounders, total testosterone levels were inversely associated with total bone mineral density. However, in the sex-stratified subgroup analysis, the association between total testosterone levels and total bone mineral density was not significant in female adolescents. There was no negative association between total testosterone and total BMD among men, adults 40 to 60 years of age, and other racial/ethnic groups. There is a negative association between total testosterone and total bone mineral density when total testosterone concentration is greater than 500 ng/dL among Non-Hispanic black.
conclusionOur statistical results show that the association between total testosterone levels and total bone mineral density varies by gender and race. Elevated total testosterone levels below 500 ng/dL have adverse effects on bone health. Total testosterone concentrations below 500 ng/dL may have no effect on bone health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.