ArticleBMC musculoskeletal disorders2021
Comparison of anterior knee laxity, stiffness, genu recurvatum, and general joint laxity in the late follicular phase and the ovulatory phase of the menstrual cycle.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Menstrual Cycle and Sport Injuries: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Intra-Rater and Test-Retest Reliability of Kinovea for the Kinematic Analysis of Squatting in Healthy Active Women.Sensors (Basel, Switzerland) · 2026Article
- Hormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.Journal of bone metabolism · 2026Article
- Menstrual Cycle and Hormonal Contraceptives in Female Athletes: Should Symptoms and Nutrition Matter More than Cycle Phase? A Narrative Review.Nutrients · 2026Review
- Relative and absolute reliability of medial knee joint space width measurement using ultrasound imaging during valgus stress testing.PloS one · 2026Article
- Menstrual cycle hormonal fluctuations and their associations with athletic performance and injury susceptibility in female athletes.Frontiers in sports and active living · 2026Review
- Reliability of Standardised High-Intensity Static Stretching on the Hamstrings over Multiple Visits.Muscles (Basel, Switzerland) · 2025Article
- Effect of Surgeon Volume on Mechanical Complications after Resection Arthroplasty with Articulating Spacer.Journal of personalized medicine · 2024Article
- Potential role of physical labor and cultural views of menstruation in high incidence of pelvic organ prolapse in Nepalese women: a comparative study across the menstrual cycle.Frontiers in medicine · 2024Article
- Changes in the mechanical properties of the thigh and lower leg muscle-tendon units during the early follicular and early luteal phases.Frontiers in sports and active living · 2024Article
- Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity.Frontiers in bioengineering and biotechnology · 2024Article
- Postural sway is not affected by estrogen fluctuations during the menstrual cycle.Physiological reports · 2023Article
- Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?Frontiers in physiology · 2023Review
- Relationship between Changes in Foot Arch and Sex Differences during the Menstrual Cycle.International journal of environmental research and public health · 2022Article
- Menstrual Cycle Changes Joint Laxity in Females-Differences between Eumenorrhea and Oligomenorrhea.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne risk factor for anterior cruciate ligament (ACL) injury may be fluctuations in female hormones. This study examined variability in joint laxity, as a risk factor for ACL injury, during the menstrual cycle.
methodsSubjects were 15 female university students with regular menstrual cycles. We measured estradiol (E2) concentration, anterior knee laxity (AKL), stiffness, genu recurvatum (GR), and general joint laxity (GJL) during the late follicular and ovulatory phases. AKL was measured as anterior tibial displacement of the femur after application of 44-, 89-, and 133-N loads on the tibia. Stiffness was calculated as Δforce/Δdisplacement at loads of 44-89 N and between 89 and 133 N. GR was measured prone, with the base of the patella distal to the edge of the bed. The University of Tokyo joint laxity test was used to evaluate GJL.
resultsE2 concentration was significantly higher in the ovulatory phase than in the late follicular phase (p = 0.018), AKL and stiffness did not differ significantly between phases, and GR and GJL were significantly higher in the ovulatory phase than in the late follicular phase (p = 0.011, 0.031).
conclusionThese findings suggest that E2 concentrations may affect GR and GJL during the menstrual cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.