ArticleBMC infectious diseases2021
The global burden and trends of maternal sepsis and other maternal infections in 204 countries and territories from 1990 to 2019.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-Care Practices for Puerperal Sepsis Prevention and Associated Factors Among Postnatal Women in Africa: A Systematic Review and Meta-Analysis.Journal of the International Association of Providers of AIDS CarePooled it
- Non-study post-partum antibiotics use and risk of maternal and neonatal infection: A secondary analysis of the A-PLUS randomized controlled trial.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Trial
- Article
- Global and China burden of maternal sepsis and infections: a systematic global burden of disease 2021 analysis with projections to 2036.The Journal of the Egyptian Public Health Association · 2026Article
- The effect of maternal infections on birth outcomes at King Abdulaziz medical city: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Global burden of maternal sepsis and other maternal infections from 1990 to 2021, with projections to 2050: risk factors and trends.Open medicine (Warsaw, Poland) · 2026Article
- Maternal deaths from sepsis in the Nordic countries during 2005-2021: A descriptive study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Assessing patient-level risk factors for evidence-based early diagnosis of maternal sepsis.BMC pregnancy and childbirth · 2025Article
- Global, regional and national burden of infections among pregnant women, 1990-2021: a prospective cohort study.BMJ open · 2025Article
- Burden and trend of maternal sepsis and other maternal infections in BRICS countries from 1990 to 2021.BMC pregnancy and childbirth · 2025Article
- Global burden of female infertility attributable to sexually transmitted infections and maternal sepsis: 1990-2021 and projections to 2050.Scientific reports · 2025Article
- Pronounced effects of the sepsis-obesity paradox in elderly and male individuals without septic shock and the role of immune-inflammatory status: an analysis of MIMIC-IV data.BMC infectious diseases · 2025Article
- Patterns of care-seeking for postpartum symptoms in urban Karachi, Pakistan: implications for intervention design.Reproductive health · 2025Article
- The Potential Impact of Antibiotic Exposure on the Microbiome and Human Health.Microorganisms · 2025Review
- Understanding gender inequities in antimicrobial resistance: role of biology, behaviour and gender norms.BMJ global health · 2025Review
- Trends in the disease burden of maternal sepsis and other maternal infections attributable to iron deficiency from 1990 to 2021 and its projection until 2050.Frontiers in public health · 2025Article
- Trends and disparities of disease burden in infections among pregnant women in 131 low-income and middle-income countries, 1990-2019.Journal of global health · 2024Article
- Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007-2019.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.Frontiers in public health · 2024Article
- Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis.Journal of intensive medicine · 2024Review
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Abstract
backgroundMaternal sepsis and other maternal infections (MSMI) have considerable impacts on women's and neonatal health, but data on the global burden and trends of MSMI are limited. Comprehensive knowledge of the burden and trend patterns of MSMI is important to allocate resources, facilitate the establishment of tailored prevention strategies and implement effective clinical treatment measures.
methodsBased on data from the Global Burden of Disease database, we analysed the global burden of MSMI by the incidence, death, disability-adjusted life year (DALY) and maternal mortality ratio (MMR) in the last 30 years. Then, the trends of MSMI were assessed by the estimated annual percentage change (EAPC) of MMR as well as the age-standardized rate (ASR) of incidence, death and DALY. Moreover, we determined the effect of sociodemographic index (SDI) on MSMI epidemiological parameters.
resultsAlthough incident cases almost stabilized from 1990 to 2015, the ASR of incidence, death, DALY and MMR steadily decreased globally from 1990 to 2019. The burden of MSMI was the highest in the low SDI region with the fastest downward trends. MSMI is still one of the most important causes of maternal death in the developed world. Substantial diversity of disease burden and trends occurred in different regions and individual countries, most of which had reduced burden and downward trends. The MMR and ASR were negatively correlated with corresponding SDI value in 2019 in 204 countries/territories and 21 regions.
conclusionThese findings highlight significant improvement in MSMI care in the past three decades, particularly in the low and low-middle SDI regions. However, the increased burden and upward trends of MSMI in a few countries and regions are raising concern, which poses a serious challenge to maternal health. More tailored prevention measures and additional resources for maternal health are urgently needed to resolve this problem.
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