Evidence map›Paper›PMID 34663254›Full record

Trial reportBMC cancer2021

Evaluating the impact of 18F-FDG-PET-CT on risk stratification and treatment adaptation for patients with muscle-invasive bladder cancer (EFFORT-MIBC): a phase II prospective trial.

Flor Verghote, Lindsay Poppe, Sofie Verbeke, Piet Dirix, Maarten Albersen, Gert De Meerleer, Charlien Berghen, Piet Ost, Geert Villeirs, Pieter De Visschere and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04724928 (Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients with Muscle Invasive Bladder Cancer), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04724928 phase2recruitingnot on this map

Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients with Muscle Invasive Bladder Cancer (EFFORT-MIBC): a Phase II Prospective Trial

TypeinterventionalSponsorUniversity Hospital, GhentRan2021 to 2030Enrolled156ConditionsMuscle-Invasive Bladder CarcinomaArmsMetastasis directed therapy (MDT), Immunotherapy, Standard of care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Radiotherapy in metastatic bladder cancer.World journal of urology · 2024
    Review
  3. Review
  4. PET Imaging in Bladder Cancer: An Update and Future Direction.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Flor VerghoteDepartment of Radiotherapy-Oncology, Ghent University Hospital, Ghent, Belgium. flor.verghote@uzgent.be.ORCID http://orcid.org/0000-0003-2218-1394
Lindsay PoppeDepartment of Radiotherapy-Oncology, Ghent University Hospital, Ghent, Belgium.
Sofie VerbekeDepartment of Pathology, Ghent University Hospital, Ghent, Belgium.
Piet DirixDepartment of Radiation-Oncology, Iridium Network, Antwerp, Belgium.
Maarten AlbersenDepartment of Urology, University Hospitals Leuven, Leuven, Belgium.
Gert De MeerleerDepartment of Radiotherapy-Oncology, University Hospitals Leuven, Leuven, Belgium.
Charlien BerghenDepartment of Radiotherapy-Oncology, University Hospitals Leuven, Leuven, Belgium.
Piet OstDepartment of Human structure and Repair, Ghent University, Ghent, Belgium.
Geert VilleirsDepartment of Radiology, Ghent University Hospital, Ghent, Belgium.
Pieter De VisschereDepartment of Radiology, Ghent University Hospital, Ghent, Belgium.
Kathia De ManDepartment of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.
Daan De MaeseneerDepartment of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
Sylvie RotteyDepartment of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
Charles Van PraetDepartment of Human structure and Repair, Ghent University, Ghent, Belgium.
Karel DecaesteckerDepartment of Human structure and Repair, Ghent University, Ghent, Belgium.
Valérie FonteyneDepartment of Radiotherapy-Oncology, Ghent University Hospital, Ghent, Belgium.
Ghent University Hospital · BEKU Leuven · BEGhent University · BEIridium Kankernetwerk · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outcome of patients with muscle-invasive bladder cancer (MIBC) remains poor, despite aggressive treatments. Inadequate primary staging, classically performed by computed tomography (CT)-imaging, could lead to inappropriate treatment and might contribute to these poor results. Although not (yet) adapted by international guidelines, several reports have indicated the superiority of

methodsEFFORT-MIBC is a multicentric prospective phase II trial aiming to include 156 patients. Eligible patients are patients with histopathology-proven MIBC or ≥ T3 on conventional imaging treated with MIBC radical treatment, without extra-pelvic metastases on conventional imaging (thoracic CT and abdominopelvic CT/ magnetic resonance imaging (MRI)). All patients will undergo radical local therapy and if eligible neo-adjuvant chemotherapy. An DISCUSSION: This is a prospective phase II trial evaluating the impact of

trial registrationThe Ethics Committee of the Ghent University Hospital (BC-07456) approved this study on 11/5/2020. The trial was registered on ClinicalTrials.gov (NCT04724928) on 21/1/2021.

Indexed as

Fluorodeoxyglucose F18RadiopharmaceuticalsHumansLymphatic MetastasisMagnetic Resonance ImagingNeoplasm InvasivenessPositron Emission Tomography Computed TomographyPrognosisProgression-Free SurvivalProspective StudiesQuality of LifeRisk AssessmentTomography, X-Ray ComputedUrinary Bladder NeoplasmsFluorodeoxyglucose F18Radiopharmaceuticals18F-FDG-PET-CTDistant metastasisImmunotherapyMetastasis-directed therapyMuscle-invasive bladder cancerNeo-adjuvant chemotherapyOligometastasisOverall survivalPrimary stagingStereotactic body radiation therapy

Identifiers

PMID34663254
PMCPMC8522089
OpenAlexW3206512142

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.