Evidence map›Paper›PMID 34663180›Full record

ArticleRNA biology2021

Two Piwis with Ago-like functions silence somatic genes at the chromatin level.

Franziska Drews, Sivarajan Karunanithi, Ulrike Götz, Simone Marker, Raphael deWijn, Marcello Pirritano, Angela M Rodrigues-Viana, Martin Jung, Gilles Gasparoni, Marcel H Schulz and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Franziska DrewsMolecular Cell Biology and Microbiology, Wuppertal University, Wuppertal, Germany.
Sivarajan KarunanithiCluster of Excellence, Multimodal Computing and Interaction, Saarland University and Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.
Ulrike GötzMolecular Cell Dynamics, Centre for Human and Molecular Biology, Saarland University, Saarbrücken, Germany.
Simone MarkerMolecular Cell Dynamics, Centre for Human and Molecular Biology, Saarland University, Saarbrücken, Germany.
Raphael deWijnMolecular Cell Dynamics, Centre for Human and Molecular Biology, Saarland University, Saarbrücken, Germany.
Marcello PirritanoMolecular Cell Biology and Microbiology, Wuppertal University, Wuppertal, Germany.
Angela M Rodrigues-VianaMolecular Cell Dynamics, Centre for Human and Molecular Biology, Saarland University, Saarbrücken, Germany.
Martin JungSchool of Medicine, Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.
Gilles GasparoniGenetics/Epigenetics, Centre for Human and Molecular Biology, Saarland University, Saarbrücken, Germany.
Marcel H SchulzCluster of Excellence, Multimodal Computing and Interaction, Saarland University and Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.
Martin SimonMolecular Cell Biology and Microbiology, Wuppertal University, Wuppertal, Germany.
Saarland University · DEUniversity of Wuppertal · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most sRNA biogenesis mechanisms involve either RNAse III cleavage or ping-pong amplification by different Piwi proteins harbouring slicer activity. Here, we follow the question why the mechanism of transgene-induced silencing in the ciliate

Indexed as

Gene SilencingArgonaute ProteinsChromatinGene Expression ProfilingHigh-Throughput Nucleotide SequencingParamecium tetraureliaProtein BindingProtozoan ProteinsRibonuclease IIIRNA InterferenceRNA, Small InterferingTransgenesArgonaute ProteinsChromatinProtozoan ProteinsRibonuclease IIIRNA, Small InterferingArgonautedicerpiwiRNA interferencesecondary siRNAssiRNAsRNA loadingtransgene-induced silencing

Identifiers

PMID34663180
PMCPMC8782163
OpenAlexW3207861884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.