Evidence map›Paper›PMID 34663099›Full record

ArticlemBio2021

Infectious SARS-CoV-2 Is Emitted in Aerosol Particles.

Seth A Hawks, Aaron J Prussin, Sarah C Kuchinsky, Jin Pan, Linsey C Marr, Nisha K Duggal

Abstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  9. Review
  10. Air Change Rate and SARS-CoV-2 Exposure in Hospitals and Residences: A Meta-Analysis.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
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  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seth A HawksDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Aaron J PrussinDepartment of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0000-0002-9991-8537
Sarah C KuchinskyDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Jin PanDepartment of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Linsey C MarrDepartment of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Nisha K DuggalDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0000-0002-9893-8069

Funding

Brain pathophysiology in SARS-CoV-2 diseaseR01NS124204 · NINDS · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2021 to 2025
$3.1M
Center for Emerging, Zoonotic, and Arthropod-borne Pathogens (Virginia Tech)HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS124204NINDS NIH HHS R01 NS124204VT | Institute for Critical Technologies and Applied Science, Virginia Tech (ICTAS)
6 · The paper itself

Abstract

Respiratory viruses such as SARS-CoV-2 are transmitted in respiratory droplets and aerosol particles, which are released during talking, breathing, coughing, and sneezing. Noncontact transmission of SARS-CoV-2 has been demonstrated, suggesting transmission via virus carried through the air. Here, we demonstrate that golden Syrian hamsters produce infectious SARS-CoV-2 in aerosol particles prior to and concurrent with the onset of mild clinical signs of disease. The average emission rate in this study was 25 infectious virions/hour on days 1 and 2 postinoculation, with average viral RNA levels 200-fold higher than infectious virus in aerosol particles. The majority of virus was contained within particles <5 μm in size. Thus, we provide direct evidence that, in hamsters, SARS-CoV-2 is an airborne virus.

Indexed as

AerosolsAnimalsChlorocebus aethiopsCOVID-19CricetinaeMesocricetusReal-Time Polymerase Chain ReactionSARS-CoV-2Vero CellsAerosolsanimal modelscoronavirustransmission

Identifiers

PMID34663099
PMCPMC8524342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.