ArticleAdvances in nutrition (Bethesda, Md.)2022
Perspective: Creatine, a Conditionally Essential Nutrient: Building the Case.
Article in Advances in nutrition (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Trial
- The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.European journal of nutrition · 2024Trial
- Effects of Four Weeks of Beta-Alanine Supplementation Combined with One Week of Creatine Loading on Physical and Cognitive Performance in Military Personnel.International journal of environmental research and public health · 2022Trial
- Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Plasma Biochemistry.Animals : an open access journal from MDPI · 2026Article
- Ubiquinol in Fertility and Reproduction: A Conditionally Essential Nutrient for Critical Early-Life Stages.Nutrients · 2026Review
- Genetic Determinants of Creatine Bioavailability and Responsiveness: Emphasis on Common Low-Impact Variants.Lifestyle genomics · 2026Review
- Part II. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2025Review
- The evolving role of creatine in public health: from food-based nutrient to supplement and beyond.Public health nutrition · 2025Review
- Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025Review
- A Comparative Analysis of Creatine, Creatinine, Amino Acid Concentrations and Indispensable Amino Acid Scores of Grain-Free and Grain-Inclusive Commercial Extruded Adult Cat Foods.Journal of animal physiology and animal nutrition · 2025Article
- Dietary Creatine and Hydration Biomarkers in the General Population: NHANES 1999-2023.Food science & nutrition · 2025Article
- Article
- Untargeted metabolomics fingerprints in seminal plasma of patients with abnormal sperm morphology using high-performance liquid chromatography and mass spectrometry.Frontiers in molecular biosciences · 2025Article
- Article
- Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017-2020.Food science & nutrition · 2024Article
- Effect of Guanidinoacetic Acid Supplementation on Growth Performance, Rumen Fermentation, Blood Indices, Nutrient Digestion, and Nitrogen Metabolism in Angus Steers.Animals : an open access journal from MDPI · 2024Article
- The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function.Frontiers in physiology · 2024Article
- Molecular nutrition in life course perspective: Pinpointing metabolic pathways to target during periconception.Maternal & child nutrition · 2024Article
- Creatine supplementation and endurance performance: surges and sprints to win the race.Journal of the International Society of Sports Nutrition · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine is a major component of energy metabolism that is abundant in human skeletal muscle, brain, and heart. Either synthesized internally or provided via an omnivorous diet, creatine is required for normal growth, development, and health. Recent advances in creatine nutrition and physiology suggest that the quantity of creatine the body naturally synthesizes is not sufficient to meet human needs. As a result, humans have to obtain enough creatine from the diet, which nominates creatine as an essential nutrient in certain circumstances. In this article, we summarize arguments that creatine should be considered a conditionally essential nutrient for humans and propose several questions that should be addressed in future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.