ArticleActa psychiatrica Scandinavica2022
Real-world evidence of age-independent electroconvulsive therapy efficacy: A retrospective cohort study.
Article in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Electroconvulsive Therapy for Catatonia in Autistic and Non-Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self-Injury Outcomes.Autism research : official journal of the International Society for Autism Research · 2026Article
- Predicting the final response and remission of electroconvulsive therapy in treating major depressive disorder: exploring the earliest predictive factors for early improvement.BMC psychiatry · 2026Article
- Why is electroconvulsive therapy for depression more effective in older age? A causal mediation analysis.Psychological medicine · 2025Article
- Age-Dependent Efficacy of Electroconvulsive Therapy in Depression: A Longitudinal Study of Symptom Trajectories and Treatment Predictions.Brain and behavior · 2025Article
- Electroconvulsive Therapy: A Scotland-Wide Naturalistic Study of 4826 Treatment Episodes.Biological psychiatry global open science · 2025Article
- Electroconvulsive therapy in autism spectrum disorders: an update to the literature.Current opinion in psychiatry · 2025Review
- Prediction of individual treatment allocation between electroconvulsive therapy or ketamine using the Personalized Advantage Index.NPJ digital medicine · 2025Article
- A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat Stress.bioRxiv : the preprint server for biology · 2025Article
- Efficacy and Safety of Neuromodulation Interventions for Autism Spectrum Disorders with Comorbidities: A Systematic Review.Neuropsychiatric disease and treatment · 2025Review
- Evaluating Anesthesia Practices, Patient Characteristics, and Outcomes in Electroconvulsive Therapy: A Two-Year Retrospective Study.Journal of clinical medicine · 2024Article
- Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis.Journal of autism and developmental disorders · 2024Article
- Ketamine or ECT? What Have We Learned From the KetECT and ELEKT-D Trials?The international journal of neuropsychopharmacology · 2024Article
- Changes in self-reported suicidal ideation during treatment with electroconvulsive therapy: A retrospective cohort study.Acta psychiatrica Scandinavica · 2023Article
- Individual Prediction of Optimal Treatment Allocation Between Electroconvulsive Therapy or Ketamine using the Personalized Advantage Index.Research square · 2023Article
- Evaluation, Treatment, and Referral of Treatment-Resistant Depression in Primary Care.The primary care companion for CNS disorders · 2023Article
- The Effects of Baseline Impaired Global Cognitive Function on the Efficacy and Cognitive Effects of Electroconvulsive Therapy in Geriatric Patients: A Retrospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Association between electroconvulsive therapy and depressive disorder from 2012 to 2021: Bibliometric analysis and global trends.Frontiers in human neuroscience · 2022Article
- Electroconvulsive Therapy: Mechanisms of Action, Clinical Considerations, and Future Directions.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesElectroconvulsive therapy (ECT) is an effective treatment for depressive disorders and approved for use in adolescents and adults, but it is unclear whether efficacy or cognitive side effect burden differs with age or if effectiveness in usual clinical practice matches that in prospective studies. We examined the effects of ECT on depression and cognition in a large clinical cohort.
methodsA retrospective cohort study of patients ages 16 and older receiving ECT between 2011 and 2020 and who were evaluated with the Quick Inventory of Depressive Symptomatology (QIDS), the Behavior and Symptom Identification Scale-24 (BASIS-24), and the Montreal Cognitive Assessment (MoCA) at baseline and after treatment #10.
resultsAmong 1698 patients, ECT was associated with a decrease in depression symptoms (QIDS reduction from 17.1 ± 4.9 to 10.1 ± 5.2) and improvement in self-reported mental health (BASIS-24 scores improved from 1.92 ± 0.55 to 1.17 ± 0.60). There was a reduction in MoCA scores from 25.8 ± 3.1 to 25.4 ± 3.1. In multivariate models, age was not associated with a differential QIDS or BASIS-24 response, but older age was associated with a lesser reduction in MoCA.
conclusionAmong 1698 patients aged 16 and older, ECT was associated with improvement in depression and overall self-reported mental health, with a slight decrease in cognition. Age was not associated with changes in efficacy, but older age was associated with a lesser cognitive change as measured by the MoCA. These results provide normative data of real-world effectiveness of ECT, and add further support to its utility in patients with severe psychiatric illness.
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