Evidence map›Paper›PMID 34662424›Full record

ArticlePlant physiology2022

Single-cell genomics in plants: current state, future directions, and hurdles to overcome.

Josh T Cuperus

Abstract read
In one paragraph

Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  5. Article
  6. Chromosome-scale genome assembly of Malcolmia littorea using long-read sequencing and single-pollen genotyping technologies.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
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  7. Article
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  9. Review
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  17. Article
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  20. A spatially resolved multiomic single-cell atlas of soybean development.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Josh T CuperusDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-8019-7733

Funding

Molecular Mechanisms of Seasonal Time MeasurementR01GM079712 · NIGMS · UNIVERSITY OF WASHINGTON · PI IMAIZUMI, TAKATO · 2007 to 2022
$3.5M
Understanding gene regulation in contextR35GM139532 · NIGMS · UNIVERSITY OF WASHINGTON · PI Christine Queitsch · 2021 to 2026
$3.3M
NIGMS NIH HHS R01 GM079712NIGMS NIH HHS R35 GM139532
6 · The paper itself

Abstract

Single-cell genomics has the potential to revolutionize the study of plant development and tissue-specific responses to environmental stimuli by revealing heretofore unknown players and gene regulatory processes. Here, I focus on the current state of single-cell genomics in plants, emerging technologies and applications, in addition to outlining possible future directions for experiments. I describe approaches to enable cheaper and larger experiments and technologies to measure multiple types of molecules to better model and understand cell types and their different states and trajectories throughout development. Lastly, I discuss the inherent limitations of single-cell studies and the technological hurdles that need to be overcome to widely apply single-cell genomics in crops to generate the greatest possible knowledge gain.

Indexed as

ForecastingGenomicsPlant Physiological PhenomenaSingle-Cell Analysis

Identifiers

PMID34662424
PMCPMC8825463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.