Evidence map›Paper›PMID 34662409›Full record

ArticleThe Journal of infectious diseases2022

Cumulative Incidence of SARS-CoV-2 Infections Among Adults in Georgia, United States, August to December 2020.

Allison T Chamberlain, Kathleen E Toomey, Heather Bradley, Eric W Hall, Mansour Fahimi, Benjamin A Lopman, Nicole Luisi, Travis Sanchez, Cherie Drenzek, Kayoko Shioda and 2 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Allison T ChamberlainDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Kathleen E ToomeyGeorgia Department of Public Health, Atlanta, Georgia, USA.
Heather BradleyDepartment of Population Health Sciences, Georgia State University School of Public Health, Atlanta, Georgia, USA.
Eric W HallDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Mansour FahimiMarketing Systems Group, Philadelphia, Pennsylvania, USA.
Benjamin A LopmanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Nicole LuisiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Travis SanchezDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Cherie DrenzekGeorgia Department of Public Health, Atlanta, Georgia, USA.
Kayoko ShiodaGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Aaron J SieglerDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-5553-7540
Patrick Sean SullivanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Population-based survey of SARS-CoV-2 infection and immune responseR01AI143875 · NIAID · EMORY UNIVERSITY · PI SIEGLER, AARON JULIUS, SULLIVAN, PATRICK SEAN · 2019 to 2023
$9.2M
California Department of HealthCenter for AIDS Research at Emory University P30AI050409Emory Covid-19 Response CollaborativeNational Institute of Allergy and Infectious Diseases 3R01AI143875-02S1NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI143875
6 · The paper itself

Abstract

backgroundReported coronavirus disease 2019 (COVID-19) cases underestimate true severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Data on all infections, including asymptomatic infections, are needed. To minimize biases in estimates from reported cases and seroprevalence surveys, we conducted a household-based probability survey and estimated cumulative incidence of SARS-CoV-2 infections adjusted for antibody waning.

methodsFrom August to December 2020, we mailed specimen collection kits (nasal swabs and blood spots) to a random sample of Georgia addresses. One household adult completed a survey and returned specimens for virus and antibody testing. We estimated cumulative incidence of SARS-CoV-2 infections adjusted for waning antibodies, reported fraction, and infection fatality ratio (IFR). Differences in seropositivity among demographic, geographic, and clinical subgroups were explored with weighted prevalence ratios (PR).

resultsAmong 1370 participants, adjusted cumulative incidence of SARS-CoV-2 was 16.1% (95% credible interval [CrI], 13.5%-19.2%) as of 16 November 2020. The reported fraction was 26.6% and IFR was 0.78%. Non-Hispanic black (PR, 2.03; 95% confidence interval [CI], 1.0-4.1) and Hispanic adults (PR, 1.98; 95% CI, .74-5.31) were more likely than non-Hispanic white adults to be seropositive.

conclusionsAs of mid-November 2020, 1 in 6 adults in Georgia had been infected with SARS-CoV-2. The COVID-19 epidemic in Georgia is likely substantially underestimated by reported cases.

Indexed as

COVID-19AdultAntibodies, ViralGeorgiaHumansIncidenceSeroepidemiologic StudiesAntibodies, ViralCOVID-19cumulative incidenceGeorgiaSARS-CoV-2seroprevalence

Identifiers

PMID34662409
PMCPMC8807152

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.