Evidence map›Paper›PMID 34662256›Full record

ReviewCell cycle (Georgetown, Tex.)2021

Dbf4-Dependent Kinase: DDK-ated to post-initiation events in DNA replication.

Andrew Dolson, Safia Mahabub Sauty, Kholoud Shaban, Krassimir Yankulov

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The yeast Dbf4 ZnCurrent genetics · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew DolsonDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Safia Mahabub SautyDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Kholoud ShabanDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Krassimir YankulovDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0001-9440-9234
University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dbf4-Dependent Kinase (DDK) has a well-established essential role at origins of DNA replication, where it phosphorylates and activates the replicative MCM helicase. It also acts in the response to mutagens and in DNA repair as well as in key steps during meiosis. Recent studies have indicated that, in addition to the MCM helicase, DDK phosphorylates several substrates during the elongation stage of DNA replication or upon replication stress. However, these activities of DDK are not essential for viability. Dbf4-Dependent Kinase is also emerging as a key factor in the regulation of genome-wide origin firing and in replication-coupled chromatin assembly. In this review, we summarize recent progress in our understanding of the diverse roles of DDK.

Indexed as

Cell Cycle ProteinsDNA ReplicationSaccharomyces cerevisiae ProteinsPhosphorylationProtein Serine-Threonine KinasesReplication OriginSaccharomyces cerevisiaeCell Cycle ProteinsDbf4 protein, S cerevisiaeProtein Serine-Threonine KinasesSaccharomyces cerevisiae Proteinscyclin dependent KinaseDbf4-dependent Kinaseorigins of DNA replicationreplication forksreplication stress

Identifiers

PMID34662256
PMCPMC8794506
OpenAlexW3206389086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.