Evidence map›Paper›PMID 34662213›Full record

ArticleInfection and immunity2022

Cyclopropane Fatty Acids Are Important for

Joyce E Karlinsey, Angela M Fung, Norah Johnston, Howard Goldfine, Stephen J Libby, Ferric C Fang

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Autophagy · 2025
    Article
  6. Review
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  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joyce E KarlinseyDepartment of Microbiology, University of Washingtongrid.34477.33 School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-3585-8301
Angela M FungDepartment of Laboratory Medicine and Pathology, University of Washingtongrid.34477.33 School of Medicine, Seattle, Washington, USA.
Norah JohnstonDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Howard GoldfineDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Stephen J LibbyDepartment of Laboratory Medicine and Pathology, University of Washingtongrid.34477.33 School of Medicine, Seattle, Washington, USA.
Ferric C FangDepartment of Laboratory Medicine and Pathology, University of Washingtongrid.34477.33 School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-3243-110X
University of Washington · USUniversity of Pennsylvania · US

Funding

THE SALMONELLA TYPHIMURIUM SIGMAE REGULONR01AI044486 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1999 to 2016
$4.9M
The Pathogenesis of Enteric FeverR01AI160130 · NIAID · UNIVERSITY OF WASHINGTON · PI Ferric C Fang · 2021 to 2026
$3.3M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI044486NIAID NIH HHS R01 AI118962NIAID NIH HHS R01 AI160130
6 · The paper itself

Abstract

A variety of eubacteria, plants, and protozoa can modify membrane lipids by cyclopropanation, which is reported to modulate membrane permeability and fluidity. The ability to cyclopropanate membrane lipids has been associated with resistance to oxidative stress in Mycobacterium tuberculosis, organic solvent stress in Escherichia coli, and acid stress in E. coli and Salmonella. In bacteria, the

Indexed as

AnimalsBacterial Physiological PhenomenaBacterial ProteinsBiosynthetic PathwaysCyclopropanesDisease Models, AnimalFatty AcidsHydrogen-Ion ConcentrationMacrophagesMiceMicrobial ViabilityMutationOxidative StressSalmonella InfectionsSalmonella typhimuriumVirulenceBacterial Proteinscyclopropane fatty acidsCyclopropanesFatty Acidscyclopropane fatty acidSalmonellavirulence

Identifiers

PMID34662213
PMCPMC8788740
OpenAlexW3206676925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.