Evidence map›Paper›PMID 34662212›Full record

ArticleInfection and immunity2022

Analysis of Six

Anita C Parker, Nathaniel L Seals, Cecile L Baccanale, Edson R Rocha

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Multiple TonB-dependent transport systems inInfection and immunity · 2026
    Article
  2. Article
  3. Sphingolipid-mediated vesiculation in multidrug-resistantApplied and environmental microbiology · 2025
    Article
  4. Genetic- and culture-based tools for studyingMicrobiology resource announcements · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. A putative siderophore receptor ofFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anita C ParkerDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina Universitygrid.255364.3, Greenville, North Carolina, USA.
Nathaniel L SealsDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina Universitygrid.255364.3, Greenville, North Carolina, USA.
Cecile L BaccanaleDepartment of Comparative Medicine, Brody School of Medicine, East Carolina Universitygrid.255364.3, Greenville, North Carolina, USA.
Edson R RochaDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina Universitygrid.255364.3, Greenville, North Carolina, USA.ORCID 0000-0002-3472-8951
East Carolina University · US

Funding

Strategies of Bacteroides fragilis to acquire iron in the intestinal tract.R21AI125921 · NIAID · EAST CAROLINA UNIVERSITY · PI ROCHA, EDSON R · 2017 to 2018
$406k
NIAID NIH HHS R21 AI125921
6 · The paper itself

Abstract

The opportunistic, anaerobic pathogen and commensal of the human large intestinal tract, Bacteroides fragilis strain 638R, contains six predicted TonB proteins, termed TonB1-6, four ExbBs orthologs, ExbB1-4, and five ExbDs orthologs, ExbD1-5. The inner membrane TonB/ExbB/ExbD complex harvests energy from the proton motive force (Δp), and the TonB C-terminal domain interacts with and transduces energy to outer membrane TonB-dependent transporters (TBDTs). However, TonB's role in activating nearly one hundred TBDTs for nutrient acquisition in B. fragilis during intestinal colonization and extraintestinal infection has not been established. In this study, we show that growth was abolished in the

Indexed as

Multigene FamilyAmino Acid SequenceAnimalsBacterial ProteinsBacteroides fragilisBacteroides InfectionsChromosome MappingDisease Models, AnimalGene OrderHost-Pathogen InteractionsIntraabdominal InfectionsMembrane ProteinsMiceMutationBacterial ProteinsMembrane ProteinstonB protein, Bacteriaanaerobic bacteriaBacteroidesB. fragilisintestinal colonizationintra-abdominal infectionTonBTonB-dependent transporter

Identifiers

PMID34662212
PMCPMC8788773
OpenAlexW3205233764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.