Evidence map›Paper›PMID 34662211›Full record

ArticleInfection and immunity2022

Host-to-Host Group A Streptococcus Transmission Causes Infection of the Lamina Propria but Not Epithelium of the Upper Respiratory Tract in MyD88-Deficient Mice.

Dylan Minor, Jacob Cavon, Thea Johnson, Savannah Ontiveros, Daniel Gao, Mark T Quinn, Benfang Lei

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dylan MinorDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Jacob CavonDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Thea JohnsonDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Savannah OntiverosDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Daniel GaoDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Mark T QuinnDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Benfang LeiDepartment of Microbiology and Cell Biology, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.ORCID 0000-0001-8133-6021
Montana State University · US

Funding

A Murine Group A Streptococcus Transmission Model for Male-Biased Acute Infection in the Mucosa of the Upper Respiratory TractR21AI153755 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI LEI, BENFANG · 2020 to 2021
$396k
NIAID NIH HHS R21 AI153755
6 · The paper itself

Abstract

To understand protective immune responses against the onset of group A Streptococcus respiratory infection, we investigated whether MyD88 KO mice were susceptible to acute infection through transmission. After commingling with mice that had intranasal group A Streptococcus (GAS) inoculation, MyD88

Indexed as

Host-Pathogen InteractionsAnimalsBiopsyDisease SusceptibilityEpitheliumGenetic Predisposition to DiseaseImmunohistochemistryMiceMice, KnockoutMyeloid Differentiation Factor 88Neutrophil InfiltrationOrgan SpecificityRespiratory MucosaRespiratory Tract InfectionsStreptococcal InfectionsStreptococcus pyogenesMyd88 protein, mouseMyeloid Differentiation Factor 88epitheliumgroup A Streptococcusinnate immunitylamina propriaMyD88pharyngitisrespiratory infectionStreptococcus pyogenestransmission

Identifiers

PMID34662211
PMCPMC8788669
OpenAlexW3205367449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.