Evidence map›Paper›PMID 34662196›Full record

ArticleAntimicrobial agents and chemotherapy2022

Analogs of Marinopyrrole A Show Enhancement to Observed

Matthew C Martens, Yan Liu, Austin G Sanford, Alexander I Wallick, Rosalie C Warner, Rongshi Li, Paul H Davis

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells.International journal for parasitology. Drugs and drug resistance · 2025
    Article
  4. Expanded Gram-Negative Activity of Marinopyrrole A.Pathogens (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew C MartensDepartment of Biology, University of Nebraska at Omahagrid.266815.e, Omaha, Nebraska, USA.ORCID 0000-0001-8547-1765
Yan LiuDepartment of Pharmaceutical Sciences, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Austin G SanfordDepartment of Biology, University of Nebraska at Omahagrid.266815.e, Omaha, Nebraska, USA.
Alexander I WallickDepartment of Biology, University of Nebraska at Omahagrid.266815.e, Omaha, Nebraska, USA.
Rosalie C WarnerDepartment of Biology, University of Nebraska at Omahagrid.266815.e, Omaha, Nebraska, USA.
Rongshi LiDepartment of Pharmaceutical Sciences, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Paul H DavisDepartment of Biology, University of Nebraska at Omahagrid.266815.e, Omaha, Nebraska, USA.ORCID 0000-0002-0526-3841
University of Nebraska at Omaha · USUniversity of Nebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

The apicomplexan parasite Toxoplasma gondii is the causative agent of toxoplasmosis, a globally distributed infection with severe clinical consequences for immunocompromised individuals and developing fetuses. There are few available treatments, and these are associated with potentially severe adverse effects. Marinopyrrole A, a compound discovered in a marine

Indexed as

Antiprotozoal AgentsToxoplasmaToxoplasmosisHumansPyrrolesAntiprotozoal Agentsmarinopyrrole APyrrolesanalogantiparasitic agentsmarinopyrroleToxoplasma gondii

Identifiers

PMID34662196
PMCPMC8765230
OpenAlexW3205738163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.