Evidence map›Paper›PMID 34661966›Full record

ArticleAngewandte Chemie (International ed. in English)2021

General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability.

Xuan Fu, Madhusudhan Reddy Gadi, Shuaishuai Wang, Jinghua Han, Ding Liu, Xi Chen, Jun Yin, Lei Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xuan FuDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Madhusudhan Reddy GadiDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Shuaishuai WangDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Jinghua HanDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Ding LiuDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Xi ChenDepartment of Chemistry, University of California, Davis, Davis, CA, 95616, USA.
Jun YinDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Lei LiDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.ORCID 0000-0002-1146-0761
Georgia State University · USUniversity of California, Davis · US

Funding

Chemoenzymatic synthesis of bacterial polysaccharidesU01GM125288 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIESSLING, LAURA L, LI, LEI · 2017 to 2020
$3.1M
A Comprehensive 5K Plus Glycan MicroarrayR44GM123820 · NIGMS · Z BIOTECH, LLC · PI LI, LEI, ZHANG, JIAN · 2021 to 2023
$1.9M
Innovative Glycomic/Glycoproteomic Investigation on Alzheimer’s DiseaseR56AG062258 · NIA · GEORGIA STATE UNIVERSITY · PI LI, LIAN, YIN, JUN · 2018 to 2018
$783k
NIA NIH HHS R56 AG062258NIA NIH HHS R56AG062258NIGMS NIH HHS R44 GM123820NIGMS NIH HHS R44GM123820NIGMS NIH HHS U01 GM125288NIGMS NIH HHS U01GM125288
6 · The paper itself

Abstract

Accessing large numbers of structurally diverse glycans and derivatives is essential to functional glycomics. We showed a general tolerance of galactosyltransferases toward uridine-diphosphate-galactosamine (UDP-GalN), which is not a commonly used sugar nucleotide donor. The property was harnessed to develop a two-step chemoenzymatic strategy for facile synthesis of novel and divergent N-acetylgalactosamine (GalNAc)-glycosides and derivatives in preparative scales. The discovery and the application of the new property of existing glycosyltransferases expand their catalytic capabilities in generating novel carbohydrate linkages, thus prompting the synthesis of diverse glycans and glycoconjugates for biological studies.

Indexed as

Carbohydrate ConformationGalactosyltransferasesHelicobacter pyloriNeisseria meningitidisUridine Diphosphate N-AcetylgalactosamineGalactosyltransferasesuridine diphosphate galactosamineUridine Diphosphate N-AcetylgalactosaminegalactosyltransferaseGalNAc-glycosidesgeneral toleranceUDP-galactosamine

Identifiers

PMID34661966
PMCPMC8720041
OpenAlexW3207587498

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.