Evidence map›Paper›PMID 34661927›Full record

ReviewJournal of the European Academy of Dermatology and Venereology : JEADV2022

Cutaneous findings following COVID-19 vaccination: review of world literature and own experience.

T Gambichler, S Boms, L Susok, H Dickel, C Finis, N Abu Rached, M Barras, M Stücker, D Kasakovski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the European Academy of Dermatology and Venereology : JEADV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  12. Long-Term Autoimmune Polyarthritis due to COVID-19 Vaccine.HCA healthcare journal of medicine · 2025
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

T GambichlerDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0001-7862-3695
S BomsDepartment of Dermatology, Christian Hospital Unna, Unna, Germany.
L SusokDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
H DickelDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
C FinisDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
N Abu RachedDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
M BarrasDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
M StückerDepartment of Dermatology, Ruhr-University Bochum, Bochum, Germany.
D KasakovskiEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing evidence that not only the novel coronavirus disease (COVID-19) but also the COVID-19 vaccines can cause a variety of skin reactions. In this review article, we provide a brief overview on cutaneous findings that have been observed since the emerging mass COVID-19 vaccination campaigns all over the world. Unspecific injection-site reactions very early occurring after the vaccination are most frequent. Type I hypersensitivity reactions (e.g. urticaria, angio-oedema and anaphylaxis) likely due to allergy to ingredients may rarely occur but can be severe. Type IV hypersensitivity reactions may be observed, including delayed large local skin lesions ("COVID arm"), inflammatory reactions in dermal filler or previous radiation sites or even old BCG scars, and more commonly morbilliform and erythema multiforme-like rashes. Autoimmune-mediated skin findings after COVID-19 vaccination include leucocytoclastic vasculitis, lupus erythematosus and immune thrombocytopenia. Functional angiopathies (chilblain-like lesions, erythromelalgia) may also be observed. Pityriasis rosea-like rashes and reactivation of herpes zoster have also been reported after COVID-19 vaccination. In conclusion, there are numerous cutaneous reaction patterns that may occur following COVID-19 vaccination, whereby many of these skin findings are of immunological/autoimmunological nature. Importantly, molecular mimicry exists between SARS-CoV-2 (e.g. the spike-protein sequences used to design the vaccines) and human components and may thus explain some COVID-19 pathologies as well as adverse skin reactions to COVID-19 vaccinations.

Indexed as

AnaphylaxisCOVID-19COVID-19 VaccinesHumansSARS-CoV-2VaccinationCOVID-19 Vaccines

Identifiers

PMID34661927
PMCPMC8656409

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.