Evidence map›Paper›PMID 34661882›Full record

ArticleEating and weight disorders : EWD2022

Changes in cognitive and behavioral control after lamotrigine and intensive dialectical behavioral therapy for severe, multi-impulsive bulimia nervosa: an fMRI case study.

Laura A Berner, Erin E Reilly, Xinze Yu, Angeline Krueger, Mary Ellen Trunko, Leslie K Anderson, Joanna Chen, Alan N Simmons, Walter H Kaye

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Laura A BernerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Erin E ReillyDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Xinze YuDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Angeline KruegerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Mary Ellen TrunkoDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Leslie K AndersonDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Joanna ChenDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Alan N SimmonsDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Walter H KayeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA. wkaye@health.ucsd.edu.ORCID http://orcid.org/0000-0002-4478-4906
University of California San Diego · USHofstra University · USUC San Diego Health System · US

Funding

The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging StudyK23MH118418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNER, LAURA A. · 2019 to 2023
$963k
Neural Bases of Self-regulatory Control in Bulimia NervosaF32MH108311 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERNER, LAURA A. · 2016 to 2018
$171k
NIMH NIH HHS F32 MH108311NIMH NIH HHS F32MH108311NIMH NIH HHS K23 MH118418NIMH NIH HHS K23MH118418
6 · The paper itself

Abstract

purposeAdults with bulimia nervosa (BN) and co-occurring emotional dysregulation and multiple impulsive behaviors are less responsive to existing interventions. Initial data suggest that the combination of Dialectical Behavior Therapy (DBT) and a mood stabilizer, lamotrigine, significantly reduces symptoms of affective and behavioral dysregulation in these patients. Identifying candidate neurobiological mechanisms of change for this novel treatment combination may help guide future randomized controlled trials and inform new and targeted treatment development. Here, we examined neurocognitive and symptom changes in a female patient with BN and severe affective and behavioral dysregulation who received DBT and lamotrigine.

methodsGo/no-go task performance data and resting-state functional MRI scans were acquired before the initiation of lamotrigine (after 6 weeks in an intensive DBT program), and again after reaching and maintaining a stable dose of lamotrigine. The patient completed a battery of symptom measures biweekly for 18 weeks over the course of treatment.

resultsAfter lamotrigine initiation, the patient made fewer errors on a response inhibition task and showed increased and new connectivity within frontoparietal and frontolimbic networks involved in behavioral and affective control. Accompanying this symptom improvement, the patient reported marked reductions in bulimic symptoms, behavioral dysregulation, and reactivity to negative affect, along with increases in DBT skills use.

conclusionImproved response inhibition and cognitive control network connectivity should be further investigated as neurocognitive mechanisms of change with combined DBT and lamotrigine for eating disorders. Longitudinal, controlled trials integrating neuroimaging and symptom measures are needed to fully evaluate the effects of this treatment. LEVEL OF EVIDENCE: IV: Evidence obtained from multiple time series with or without the intervention, such as case studies.

Indexed as

Bulimia NervosaAdultBehavior ControlBehavior TherapyCognitionFemaleHumansImpulsive BehaviorLamotrigineMagnetic Resonance ImagingLamotrigineBinge eatingBulimia nervosaCognitive controlDialectical behavior therapyLamotriginePurging

Identifiers

PMID34661882
PMCPMC9122851
OpenAlexW3207429776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.