ArticleInternational journal of behavioral medicine2022
Daily Stressors, Emotion Dynamics, and Inflammation in the MIDUS Cohort.
Article in International journal of behavioral medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Inflammation, fronto-amygdala connectivity, and negative affective reactivity to daily stress in adolescents.Brain, behavior, & immunity - health · 2026Article
- Longitudinal profiles of affect dynamics in middle and later life: A latent transition analysis.Psychology and aging · 2026Article
- The National Study of Daily Experiences: Protocol for Assessments of Daily Stress, Well-Being, Health, and Salivary Biomarkers in a Longitudinal Cohort.JMIR research protocols · 2025Article
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Parent and adolescent emotional variability and adolescent psychopathology.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Article
- Mean affect and affect variability may interact to predict inflammation.Brain, behavior, and immunity · 2023Article
- The Mediating Role of Daily Affect Dynamics in Bidirectional and Longitudinal Associations Between Depressive Symptoms and Inflammation.Biopsychosocial science and medicineArticle
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe current study (1) examined links between daily stressors and inflammation and (2) tested whether negative emotion dynamics (emotional variability) is one pathway through which stressors are linked to inflammation.
methodA cross-sectional sample of 986 adults (aged 35-86 years, 57% female) from MIDUS reported daily stressor frequency and severity and negative emotions on 8 consecutive nights. Negative emotion variability (intraindividual standard deviation), controlling for overall mean level (intraindividual mean), was the focus of the current study. Interleukin-6 (IL-6) and C-reactive protein (CRP) were assayed from blood drawn at a clinic visit. Regression models adjusted for demographics, health factors, and the time between assessments.
resultsMore severe daily stressors were associated with higher CRP, but this effect was accounted for by covariates. More frequent daily stressors were associated with lower IL-6 and CRP. In follow-up analyses, significant interactions between stressor severity and frequency suggested that participants with lower stressor severity and higher stressor frequency had the lowest levels of IL-6 and CRP, whereas those with higher stressor severity had the highest levels of IL-6 and CRP, regardless of frequency. Daily stressor frequency and severity were positively associated with negative emotion variability, but variability was not linearly associated with inflammation and did not operate as a mediator.
conclusionAmong midlife and older adults, daily stressor frequency and severity may interact and synergistically associate with inflammatory markers, potentially due to these adults being advantaged in other ways related to lower inflammation, or in a pattern aligning with hormetic stress, where frequent but manageable stressors may yield physiological benefits, or both. Negative emotion variability does not operate as a mediator. Additional work is needed to reliably measure and test other emotion dynamic metrics that may contribute to inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.