Evidence map›Paper›PMID 34661748›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

The predictive trifecta? Fatigue, pain, and anxiety severity forecast the suffering profile of children with cancer.

Meaghann S Weaver, Jichuan Wang, Katie A Greenzang, Molly McFatrich, Pamela S Hinds

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Prevalence and predictors of psychological distress among patients with thyroid cancer during transitional period in China: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meaghann S WeaverDepartment of Pediatrics, University of Nebraska, Nebraska Medicine, Omaha, NE, 68198-2155, USA. meweaver@childrensomaha.org.ORCID http://orcid.org/0000-0003-2310-0111
Jichuan WangDepartment of Pediatrics, The George Washington University, Washington, DC, USA.
Katie A GreenzangDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Molly McFatrichDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Pamela S HindsDepartment of Pediatrics, The George Washington University, Washington, DC, USA.

Funding

Creating and Validating Child Adverse Event Reporting in Oncology TrialsR01CA175759 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REEVE, BRYCE B · 2013 to 2018
$3.4M
Enhancing Meaningfulness and Usefulness of Pediatric and Caregiver PROMIS Measures Across Illness GroupsU19AR069522 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REEVE, BRYCE B, SCHANBERG, LAURA E · 2015 to 2015
$2.9M
division of cancer epidemiology and genetics, national cancer institute R01CA175759NCI NIH HHS R01 CA175759NIAMS NIH HHS U19 AR069522NIAMS NIH HHS U19AR069522
6 · The paper itself

Abstract

backgroundFatigue, pain, and anxiety, symptoms commonly experienced by children with cancer, may predict pediatric symptom suffering profile membership that is amenable to treatment.

methodsThree latent profiles (Low, Medium, and High symptom suffering) from 436 pediatric patients undergoing cancer care were assessed for association with three single-item symptoms and socio-demographic variables.

resultsPediatric-PRO-CTCAE fatigue, pain, and anxiety severity scores at baseline were highly and significantly associated with the Medium and High Suffering profiles comprised of PROMIS pediatric symptom and function measures. The likelihood of membership in the Medium Suffering group was 11.37 times higher for patients who experienced fatigue severity than those with did not, while experience of pain severity increased the likelihood of the child's membership in the Medium Suffering profile by 2.59 times and anxiety by 3.67 times. The severity of fatigue increased the likelihood of presence in the High Suffering group by 2.99 times while pain severity increased the likelihood of the child's membership in the High Suffering profile by 6.36 times and anxiety by 16.75 times. Controlling for experience of symptom severity, older patients were more likely to be in the Higher or Medium Suffering profile than in the Low Suffering profile; no other socio-demographic or clinical variables had a significant effect on the latent profile classification.

conclusionClinician knowledge of the strong association between fatigue, pain, and anxiety severity and suffering profiles may help focus supportive care to improve the cancer experience for children most at risk from time of diagnosis through treatment.

Indexed as

AnxietyNeoplasmsChildFatigueHumansPainPain MeasurementAnxietyFatiguePainPatient-reported outcomesPediatric cancerPediatric oncologySupportive care

Identifiers

PMID34661748
PMCPMC8919269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.