Evidence map›Paper›PMID 34661742›Full record

ArticleClinical oral investigations2022

Efficacy of biocompatible trilayers nanofibrous scaffold with/without allogeneic adipose-derived stem cells on class II furcation defects of dogs' model.

Alaa M Mansour, Sarah Yahia, Hassan Reda Hassan Elsayed, Saied A E El-Attar, Mohammed E Grawish, Youssry M El-Hawary, Ibrahim M El-Sherbiny

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Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alaa M MansourDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
Sarah YahiaNanomedicine Labs, Center of Materials Sciences (CMS), Zewail City of Science and Technology, 6th of October, Giza, 12578, Egypt.
Hassan Reda Hassan ElsayedDepartment of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.
Saied A E El-AttarDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
Mohammed E GrawishDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
Youssry M El-HawaryDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
Ibrahim M El-SherbinyNanomedicine Labs, Center of Materials Sciences (CMS), Zewail City of Science and Technology, 6th of October, Giza, 12578, Egypt. ielsherbiny@zewailcity.edu.eg.
Mansoura University · EGZewail City of Science and Technology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the regenerative capacity of a newly-developed polycaprolactone (PCL)-based nanofibrous composite scaffold either alone or in combination with adipose-derived mesenchymal stem cells (ADSCs) as a treatment modality for class II furcation defects. MATERIALS AND

methodsAfter ADSCs isolation and scaffold characterization, the mandibular premolars of adult male mongrel dogs were selected and randomly assigned into three equal groups. In group I, class II furcation defects were surgically induced to the inter-radicular bone. While class II furcation defects of group II were induced as in group I. In addition, the defects were filled with the prefabricated scaffold. Moreover, class II furcation defects of group III were induced as in group II and instead the defects were filled with the prefabricated scaffold seeded with ADSCs. The dogs were sacrificed at 30 days or at 60 days. Periodontal wound healing/regeneration was evaluated by radiological examination using cone beam computed tomography and histologically using ordinary, histochemical, and immunohistochemical staining.

resultsIn the two examination periods, group II defects compared to group I, and group III compared to the other groups showed a decrease in defect dimensions radiographically. Histologically, histochemically, and immunohistochemically, they significantly demonstrated better periodontal wound healing/regeneration, predominant collagen type I of newly formed bone and periodontal ligament with a significant increase in the immunoreactivity of vascular endothelial growth factor and osteopontin.

conclusionsThe newly fabricated nanofibrous scaffold has enhanced periodontal wound healing/regeneration of class II furcation defects with further enhancement achieved when ADSCs seeded onto the scaffold before implantation. CLINICAL RELEVANCE: The implementation of our newly-developed PCL-based nanofibrous composite scaffolds in class II furcation defect either alone or in conjunction with ADSCs can be considered as a suitable treatment modality to allow periodontal tissues regeneration.

Indexed as

Furcation DefectsHematopoietic Stem Cell TransplantationNanofibersAnimalsBone RegenerationDental CementumDogsGuided Tissue Regeneration, PeriodontalMaleVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AAdipose-derived mesenchymal stem cellsAlginateClass II furcation defectsHydroxyapatite nanoneedlesPolycaprolactone nanofibers

Identifiers

PMID34661742
OpenAlexW3205038358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.