Evidence map›Paper›PMID 34661736›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Clinical findings in eyes with BEST1-related retinopathy complicated by choroidal neovascularization.

Mai Miyagi, Jun Takeuchi, Yoshito Koyanagi, Kei Mizobuchi, Takaaki Hayashi, Yasuki Ito, Hiroko Terasaki, Koji M Nishiguchi, Shinji Ueno

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Polypoidal choroidal vasculopathy in a patient with DMPK-associated myotonic dystrophy.Documenta ophthalmologica. Advances in ophthalmology · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mai MiyagiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jun TakeuchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshito KoyanagiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kei MizobuchiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Yasuki ItoDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroko TerasakiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Koji M NishiguchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shinji UenoDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. ueno@med.nagoya-u.ac.jp.
Nagoya University · JPJikei University School of Medicine · JPFujita Health University · JP

Funding

japan society for the promotion of science 19K09928japan society for the promotion of science 21K0975
6 · The paper itself

Abstract

purposeTo determine the characteristics of eyes diagnosed with Best vitelliform macular dystrophy (BVMD) and autosomal recessive bestrophinopathy (ARB) complicated by choroidal neovascularization (CNV).

methodsThis was a retrospective, multicenter observational case series. Fourteen genetically confirmed BVMD patients and 9 ARB patients who had been examined in 2 ophthalmological institutions in Japan were studied. The findings in a series of ophthalmic examinations including B-scan optical coherence tomography (OCT) and OCT angiography (OCTA) were reviewed.

resultsCNV was identified in 5 eyes (17.9%) of BVMD patients and in 2 eyes (11.1%) of ARB patients. Three of 5 eyes with BVMD were classified as being at the vitelliruptive stage and 2 eyes at the atrophic stage. The CNV in 2 BVMD eyes were diagnosed as exudative because of acute visual acuity reduction, retinal hemorrhage, and intraretinal fluid, while the CNV in 3 BVMD eyes and 2 ARB eyes were diagnosed as non-exudative. The visual acuity of the two eyes with exudative CNV did not improve despite anti-VEGF treatments. None of the eyes with non-exudative CNV had a reduction of their visual acuity for at least 4 years. All of the CNV were located within hyperreflective materials which were detected in 16 eyes (57.1%) of the BVMD eyes and in 7 eyes (38.9%) of the ARB eyes.

conclusionsCNV is a relatively common complication in BEST1-related retinopathy in Asian population as well. The prognosis of eyes with exudative CNV is not always good, and OCTA can detect CNV in eyes possessing hyperreflective materials.

Indexed as

BestrophinsChoroidal NeovascularizationRetinal DiseasesVitelliform Macular DystrophyFluorescein AngiographyHumansJapanRetrospective StudiesTomography, Optical CoherenceBEST1 protein, humanBestrophinsAutosomal recessive bestrophinopathyBest vitelliform macular dystrophyChoroidal neovascularizationHyperreflective materialsOptical coherence tomography angiography

Identifiers

PMID34661736
OpenAlexW3206042298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.