ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2022
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Global geographic and socioeconomic disparities in COVID-associated acute kidney injury: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis.Renal failure · 2023Pooled it
- Kidney health in the COVID-19 pandemic: An umbrella review of meta-analyses and systematic reviews.Frontiers in public health · 2022Pooled it
- Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis.Jornal brasileiro de nefrologiaPooled it
- Prognosis of patients with a history of organ transplantation during active COVID-19 infection.BMC infectious diseases · 2025Article
- Acute kidney injury and in-hospital mortality in COVID-19: a causal analysis using directed acyclic graphs.Journal of nephrology · 2025Article
- Impact of vaccination on the development of acute kidney injury in Japanese COVID-19 patients: a retrospective observational analysis.Clinical and experimental nephrology · 2025Observational
- Persistent Inflammation, Maladaptive Remodeling, and Fibrosis in the Kidney Following Long COVID-like MHV-1 Mouse Model.Diseases (Basel, Switzerland) · 2025Article
- Long-term kidney outcomes after COVID-19: a matched cohort study using the OpenSAFELY platform.The Lancet regional health. Europe · 2025Article
- Observational
- The effects of urine alkalinization on kidney function in critically ill patients with COVID-19: a proof-of-concept randomized clinical trial.Intensive care medicine experimental · 2025Article
- Thrombotic microangiopathy with irreversible renal function in a CKD patient following COVID-19: case report.Frontiers in medicine · 2025Article
- Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients - A Single-Center Cohort Study.International journal of general medicine · 2025Article
- Survival of critically ill people with COVID-19 and acute kidney injury undergoing hemodialysis in public and private hospitals in Joinville: a cohort study, 2020-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Clinical Pharmacokinetics and Safety of Remdesivir in Phase I Participants with Varying Degrees of Renal Impairment.Clinical pharmacokinetics · 2025Article
- Kidney Function Decline After COVID-19 Infection.JAMA network open · 2024Article
- Acute kidney injury and COVID-19: the predictive power of BUN/albumin ratio for renal replacement therapy requirement.Irish journal of medical science · 2024Article
- Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice.Viruses · 2024Article
- A study of hospitalized COVID-19 patients with AKI in a setting of multiracial developing country.BMC nephrology · 2024Article
- Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study.Annals of intensive care · 2024Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundAcute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race.
methodsA prospective multicentre cohort study was performed using patients admitted to 254 UK hospitals with COVID-19 between 17 January 2020 and 5 December 2020.
resultsOf 85 687 patients, 2198 (2.6%) received acute kidney replacement therapy (KRT). Of 41 294 patients with biochemistry data, 13 000 (31.5%) had biochemical AKI: 8562 stage 1 (65.9%), 2609 stage 2 (20.1%) and 1829 stage 3 (14.1%). The main risk factors for KRT were chronic kidney disease (CKD) [adjusted odds ratio (aOR) 3.41: 95% confidence interval 3.06-3.81], male sex (aOR 2.43: 2.18-2.71) and Black race (aOR 2.17: 1.79-2.63). The main risk factors for biochemical AKI were admission respiratory rate >30 breaths per minute (aOR 1.68: 1.56-1.81), CKD (aOR 1.66: 1.57-1.76) and Black race (aOR 1.44: 1.28-1.61). There was a gradated rise in the risk of 28-day mortality by increasing severity of AKI: stage 1 aOR 1.58 (1.49-1.67), stage 2 aOR 2.41 (2.20-2.64), stage 3 aOR 3.50 (3.14-3.91) and KRT aOR 3.06 (2.75-3.39). AKI rates peaked in April 2020 and the subsequent fall in rates could not be explained by the use of dexamethasone or remdesivir.
conclusionsAKI is common in adults hospitalized with COVID-19 and it is associated with a heightened risk of mortality. Although the rates of AKI have fallen from the early months of the pandemic, high-risk patients should have their kidney function and fluid status monitored closely.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.