Evidence map›Paper›PMID 34661390›Full record

ArticleJournal of medicinal chemistry2021

Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin.

Federico Capuana, Alkystis Phinikaridou, Rachele Stefania, Sergio Padovan, Begoña Lavin, Sara Lacerda, Eyad Almouazen, Yves Chevalier, Laurence Heinrich-Balard, René M Botnar and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Biomedical Applications of Gadolinium-Containing Biomaterials: Not Only MRI Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 5 countries.

Federico CapuanaDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, Turin 10126, Italy.
Alkystis PhinikaridouSchool of Biomedical Engineering and Imaging Sciences, King's College London, Westminster Bridge Road, London SE1 7EH, United Kingdom.
Rachele StefaniaDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, Turin 10126, Italy.
Sergio PadovanInstitute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, Torino 10126, Italy.
Begoña LavinSchool of Biomedical Engineering and Imaging Sciences, King's College London, Westminster Bridge Road, London SE1 7EH, United Kingdom.
Sara LacerdaCentre de Biophysique Moléculaire, CNRS, UPR 4301, Université d'Orléans, Rue Charles Sadron, Orléans Cedex 2 45071, France.
Eyad AlmouazenCNRS, LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, 43 boulevard du 11 novembre 1918, Villeurbanne 69622, France.
Yves ChevalierCNRS, LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, 43 boulevard du 11 novembre 1918, Villeurbanne 69622, France.ORCID 0000-0002-7526-5658
Laurence Heinrich-BalardINSA Lyon, CNRS, MATEIS, UMR5510, Univ Lyon, Université Claude Bernard Lyon 1, Villeurbanne 69100, France.
René M BotnarSchool of Biomedical Engineering and Imaging Sciences, King's College London, Westminster Bridge Road, London SE1 7EH, United Kingdom.
Silvio AimeIRCCS SDN, Napoli 80100, Italy.
Giuseppe DigilioDepartment of Science and Technologic Innovation, Università del Piemonte Orientale ″Amedeo Avogadro″, Viale T. Michel 11, Alessandria 15121, Italy.ORCID 0000-0003-2397-2913
Université Claude Bernard Lyon 1 · FRUniversity of Turin · ITInstitute of Biostructure and Bioimaging · ITKing's College London · GBPontificia Universidad Católica de Chile · CLSDN Istituto di Ricerca Diagnostica e Nucleare · ITUniversidad Complutense de Madrid · ESUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversité d'Orléans · FR

Funding

British Heart Foundation RE/08/03British Heart Foundation RG/12/1/29262British Heart Foundation RG/20/1/34802Wellcome TrustWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Dysfunctional elastin turnover plays a major role in the progression of atherosclerotic plaques. Failure of tropoelastin cross-linking into mature elastin leads to the accumulation of tropoelastin within the growing plaque, increasing its instability. Here we present Gd

Indexed as

Magnetic Resonance ImagingAnimalsAtherosclerosisContrast MediaDisease Models, AnimalElastinGadoliniumMaleMiceMice, Inbred C57BLMice, KnockoutMolecular StructureSurface Plasmon ResonanceTropoelastinContrast MediaElastinGadoliniumTropoelastin

Identifiers

PMID34661390
PMCPMC8558862
OpenAlexW3205113005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.