Evidence map›Paper›PMID 34661384›Full record

ArticleACS chemical biology2021

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products.

Muhammad N Ahmed, Matti Wahlsten, Jouni Jokela, Matthias Nees, Ulf-Håkan Stenman, Danillo O Alvarenga, Tomas Strandin, Kaarina Sivonen, Antti Poso, Perttu Permi and 3 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Secondary metabolism ofApplied and environmental microbiology · 2026
    Review
  4. Article
  5. Review
  6. Biosynthesis of guanidine-containing natural products in cyanobacteria.Journal of industrial microbiology & biotechnology · 2024
    Review
  7. The Chemistry of Phytoplankton.Chemical reviews · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Muhammad N AhmedDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.
Matti WahlstenDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.ORCID 0000-0002-4107-1695
Jouni JokelaDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.ORCID 0000-0001-5096-3575
Matthias NeesDepartment of Biochemistry and Molecular Biology, Medical University in Lublin, ul. Chodzki 1, Lublin 20-093, Poland.
Ulf-Håkan StenmanDepartment of Clinical Chemistry and Haematology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, P.O. Box 63, Helsinki FIN-00014, Finland.
Danillo O AlvarengaDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.ORCID 0000-0002-3666-2220
Tomas StrandinDepartment of Virology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki FIN-00014, Finland.
Kaarina SivonenDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.ORCID 0000-0002-2904-0458
Antti PosoSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, Kuopio FIN-70211, Finland.ORCID 0000-0003-4196-4204
Perttu PermiDepartment of Biological and Environmental Science, University of Jyväskylä, P.O. Box 35, Jyväskylä FI-40014, Finland.
Mikko Metsä-KeteläDepartment of Biochemistry, University of Turku, Turku FIN-20014, Finland.ORCID 0000-0003-3176-2908
Hannu KoistinenDepartment of Clinical Chemistry and Haematology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, P.O. Box 63, Helsinki FIN-00014, Finland.
David P FewerDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Biocenter 1, P.O. Box 56, Helsinki FIN-00014, Finland.ORCID 0000-0003-3978-4845
University of Helsinki · FIMedical University of Lublin · PLUniversity of Copenhagen · DKUniversity of Eastern Finland · FIUniversity of Jyväskylä · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serine proteases regulate many physiological processes and play a key role in a variety of cancers. Aeruginosins are a family of natural products produced by cyanobacteria that exhibit pronounced structural diversity and potent serine protease inhibition. Here, we sequenced the complete genome of

Indexed as

Azabicyclo CompoundsBiological ProductsCell Line, TumorCell ProliferationGenes, BacterialHumansNodulariaTrypsin InhibitorsAzabicyclo CompoundsBiological ProductssuomilideTrypsin Inhibitors

Identifiers

PMID34661384
PMCPMC8609519
OpenAlexW3206516422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.