ArticlePest management science2022
Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti.
Article in Pest management science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Repellent effects of insecticides against Aedes aegypti: a systematic review.Parasites & vectors · 2025Pooled it
- Commercial permethrin elicits chemoreceptive responses on different Anopheles gambiae sensory appendages.Pest management science · 2026Article
- Odor repellency and neuronal responses of commercial products towards Anopheles mosquitoes.Malaria journal · 2025Article
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- Making scents of mosquito repellents.Trends in parasitology · 2025Review
- The BiteBarrier perimeter: A passive spatial device for tick control and bite prevention.Current research in parasitology & vector-borne diseases · 2025Article
- Preparation ofInsects · 2024Article
- Evaluating human landing catches as a measure of mosquito biting and the importance of considering additional modes of action.Scientific reports · 2024Article
- Occupational exposure to malaria, leishmaniasis and arbovirus vectors in endemic regions: A systematic review.Current research in parasitology & vector-borne diseases · 2024Review
- Non-contact detection of pyrethroids widely used in vector control by Anopheles mosquitoes.PloS one · 2024Article
- Insecticidal and Repellent Properties of Rapid-Acting Fluorine-Containing Compounds againstACS infectious diseases · 2023Article
- Methanolic Extracts ofPlants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundUse of pyrethroid insecticides is a pivotal strategy for mosquito control globally. Commonly known for their insecticidal activity by acting on voltage-gated sodium channels, pyrethroids, such as bioallethrin and transfluthrin, are used in mosquito coils, emanators and other vaporizers to repel mosquitoes and other biting arthropods. However, whether specific olfactory receptor neurons are activated by pyrethroids to trigger spatial repellency remains unknown.
resultsWe used behavioral and electrophysiological approaches to elucidate the mechanism of bioallethrin repellency in Aedes aegypti, a major vector of dengue, yellow fever, Zika and chikungunya viruses. We found that bioallethrin elicits spatial (i.e. non-contact) repellency and activates a specific type of olfactory receptor neuron in mosquito antennae. Furthermore, bioallethrin repellency is significantly reduced in a mosquito mutant of Orco, an obligate olfactory co-receptor that is essential for the function of odorant receptors (Ors). These results indicate that activation of specific Or(s) by bioallethrin contributes to bioallethrin repellency. In addition, bioallethrin repellency was reduced in a pyrethroid-resistant strain that carries two mutations in the sodium channel gene that are responsible for knockdown resistance (kdr) to pyrethroids, indicating a role of activation of sodium channels in bioallethrin repellency.
conclusionResults from this study show that bioallethrin repellency is likely to be the result of co-activation of Or(s) and sodium channels. These findings not only contribute to our understanding of the modes of action of volatile pyrethroids in spatial repellency, but also provide a framework for developing new repellents based on the dual-target mechanism revealed. © 2021 Society of Chemical Industry.
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Registered trials
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