ArticleEMBO reports2021
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.
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Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The positive relationship between androgen receptor splice variant-7 expression and the risk of castration-resistant prostate cancer: A cumulative analysis.Frontiers in oncology · 2023Pooled it
- Breaking the bonds: targeting protein dimerization for prostate cancer therapy.Endocrinology · 2026Review
- A novel androgen receptor gene splice site mutation induces aberrant mRNA splicing and internal in-frame deletion in androgen insensitivity syndrome.BMC medical genomics · 2026Article
- Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer.Molecular oncology · 2026Article
- Automated FRAP microscopy for high-throughput analysis of protein dynamics in chromatin organization and transcription.FEBS open bio · 2025Article
- Coregulators determine androgen receptor activity in prostate cancer.Bioscience reports · 2025Review
- Androgen receptor inhibitors in treating prostate cancer.Asian journal of andrology · 2025Review
- Androgens Suppress Corticosteroid Binding Globulin in Male Mice, Affecting the Endocrine Stress Response.Endocrinology · 2024Article
- Article
- New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium.Journal of translational medicine · 2024Article
- Article
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- Targeting sex steroid biosynthesis for breast and prostate cancer therapy.Nature reviews. Cancer · 2023Review
- Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer.Protein science : a publication of the Protein Society · 2023Article
- Double trouble for prostate cancer: synergistic action of AR blockade and PARPi in non-HRR mutated patients.Frontiers in oncology · 2023Review
- N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice.Endocrinology · 2022Article
- The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2.International journal of molecular sciences · 2022Article
- The role of ubiquitination in spinal and bulbar muscular atrophy.Frontiers in molecular neuroscience · 2022Review
- Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy.Frontiers in molecular neuroscience · 2022Review
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 5 countries.
Sarah El KharrazDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1444-2531
Vanessa DuboisDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8894-2980
Martin E van RoyenDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0002-6814-0996
Adriaan B HoutsmullerDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0003-0967-0740
Ekatarina PavlovaInstitute of Experimental Morphology Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria.ORCID 0000-0002-8821-653X
Nina AtanassovaInstitute of Experimental Morphology Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria.ORCID 0000-0002-9032-3588
Tien NguyenDepartment of Chemistry, KU Leuven, Leuven, Belgium.ORCID 0000-0002-6300-0302
Arnout VoetDepartment of Chemistry, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3329-2703
Roy EerlingsDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9661-8312
Florian HandleDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7558-5635
Stefan PrekovicDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7051-9321
Elien SmeetsDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-0975-5253
Lisa MorisDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Wout DevliesDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0003-0725-6300
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-9633-2805
Matti PoutanenDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-8953-1734
Kevin J VerstrepenVIB Laboratory for Systems Biology and KU Leuven Laboratory for Genetics and Genomics, VIB - KU Leuven Center for Microbiology, Leuven, Belgium.ORCID 0000-0002-3077-6219
Geert CarmelietDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8324-4462
Kaisa-Mari LaunonenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-2770-0464
Laura HelminenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-0870-9319
Jorma J PalvimoInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-2373-0578
Claude LibertVIB Center for Inflammation Research, VIB, Ghent, Belgium.ORCID 0000-0001-6408-036X
Dirk VanderschuerenDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1395-0104
Christine Helsen *Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1048-2798
Frank Claessens *Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8676-7709
KU Leuven · BEUniversity of Eastern Finland · FIBulgarian Academy of Sciences · BGErasmus MC · NLGhent University · BEThe Netherlands Cancer Institute · NLUniversity of Gothenburg · SEUniversity of Turku · FIVIB-KU Leuven Center for Cancer Biology · BE
Funding
PROJECT 3 - Steroid-Metabolic Interactions In the Control of GnRH NeuronsU54HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MARSHALL, JOHN C · 1998 to 2013
$16.5MTestosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6MCORE--MOLECULAR BIOLOGYP30HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SHUPNIK, MARGARET A · 1993 to 1997
–NICHD NIH HHS P30 HD028934NICHD NIH HHS P50 HD028934NICHD NIH HHS U54 HD028934
Abstract
Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model with disrupted dimerization of the AR LBD (AR
Indexed as
Receptors, AndrogenAnimalsBinding SitesDimerizationLigandsMaleMiceTranscriptional ActivationLigandsReceptors, Androgenandrogen receptorchromatin bindingdimerizationligand-binding domaintranscriptional activation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.