ArticleThe EMBO journal2021
Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.
Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Therapeutic Values of General Anesthetics: From Developmental Neurotoxicity to Neurotherapeutic Agents.Current neuropharmacology · 2026Review
- MeCP2 regulates telencephalic development in human cerebral organoids.Cell reports · 2025Article
- Effect ofIBRO neuroscience reports · 2025Article
- Development of GABAergic Interneurons in the Human Cerebral Cortex.The European journal of neuroscience · 2025Review
- Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches.Heliyon · 2025Review
- Artificial Intelligence: Fundamentals and Breakthrough Applications in Epilepsy.Epilepsy currents · 2024Review
- In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.Nature methods · 2023Article
- Article
- Biallelic SHQ1 variants in early infantile hypotonia and paroxysmal dystonia as the leading manifestation.Human genetics · 2023Article
- Unlocking Neural Function with 3D In Vitro Models: A Technical Review of Self-Assembled, Guided, and Bioprinted Brain Organoids and Their Applications in the Study of Neurodevelopmental and Neurodegenerative Disorders.International journal of molecular sciences · 2023Review
- Non-cell-autonomous regulation of interneuron specification mediated by extracellular vesicles.Science advances · 2023Article
- Development and Application of Brain Region-Specific Organoids for Investigating Psychiatric Disorders.Biological psychiatry · 2023Review
- Human cerebral organoids - a new tool for clinical neurology research.Nature reviews. Neurology · 2022Review
- Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.The EMBO journal · 2021Article
- Classics never get old: neurotransmitters shape human cortical interneuron migration.The EMBO journal · 2021Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Inhibitory GABAergic interneurons migrate over long distances from their extracortical origin into the developing cortex. In humans, this process is uniquely slow and prolonged, and it is unclear whether guidance cues unique to humans govern the various phases of this complex developmental process. Here, we use fused cerebral organoids to identify key roles of neurotransmitter signaling pathways in guiding the migratory behavior of human cortical interneurons. We use scRNAseq to reveal expression of GABA, glutamate, glycine, and serotonin receptors along distinct maturation trajectories across interneuron migration. We develop an image analysis software package, TrackPal, to simultaneously assess 48 parameters for entire migration tracks of individual cells. By chemical screening, we show that different modes of interneuron migration depend on distinct neurotransmitter signaling pathways, linking transcriptional maturation of interneurons with their migratory behavior. Altogether, our study provides a comprehensive quantitative analysis of human interneuron migration and its functional modulation by neurotransmitter signaling.
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