Evidence map›Paper›PMID 34661168›Full record

ArticleCurrent research in food science2021

Alginate-based microparticles structured with different biopolymers and enriched with a phenolic-rich olive leaves extract: A physico-chemical characterization.

Federica Flamminii, Maria Paciulli, Alessandro Di Michele, Paola Littardi, Eleonora Carini, Emma Chiavaro, Paola Pittia, Carla Daniela Di Mattia

Open access · goldAbstract read
In one paragraph

Article in Current research in food science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Alginate-Based Encapsulation ofFood science & nutrition · 2026
    Article
  3. Article
  4. Design of Polymeric Delivery Systems forFoods (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Federica FlamminiiFaculty of Bioscience and Technology for Agriculture, Food and Environment, University of Teramo, Via Balzarini 1, 64100, Teramo, Italy.
Maria PaciulliDepartment of Food and Drug, University of Parma, Parco Area Delle Scienze 27/A, 43124, Parma, Italy.
Alessandro Di MicheleDepartment of Physics and Geology, University of Perugia, Via Pascoli, 06123, Perugia, Italy.
Paola LittardiDepartment of Food and Drug, University of Parma, Parco Area Delle Scienze 27/A, 43124, Parma, Italy.
Eleonora CariniDepartment of Food and Drug, University of Parma, Parco Area Delle Scienze 27/A, 43124, Parma, Italy.
Emma ChiavaroDepartment of Food and Drug, University of Parma, Parco Area Delle Scienze 27/A, 43124, Parma, Italy.
Paola PittiaFaculty of Bioscience and Technology for Agriculture, Food and Environment, University of Teramo, Via Balzarini 1, 64100, Teramo, Italy.
Carla Daniela Di MattiaFaculty of Bioscience and Technology for Agriculture, Food and Environment, University of Teramo, Via Balzarini 1, 64100, Teramo, Italy.
University of Parma · ITUniversity of Teramo · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Encapsulation of olive leaves extracts (OLE), rich of healthy components like Oleuropein, Hydroxytyrosol and Verbascoside, represents a new challenge to improve stability and nutritional value of food as well as a way to recover value added compounds from by-products, contributing to a more sustainable food system. In this context, OLE-loaded microbeads of Na alginate alone or in combination with Pectin, Na Caseinate or Whey protein isolates, were produced by emulsification internal ionotropic gelation. Encapsulation efficiency of the main phenolic compounds (Oleuropein, Hydroxytyrosol, Verbascoside) was carried out along with microparticles morphological characterization by scanning electron microscopy (SEM), thermal properties by differential scanning calorimetry (DSC) and color. Encapsulation efficiency resulted higher for Alginate/Pectin, whilst Alginate/Caseinate was the less performing system, probably due to the lower interaction with polyphenols. SEM revealed collapsed structures and continuous smooth surfaces for Alginate and Alginate/Pectin microbeads while more regular structures and porous surfaces were observed for Alginate/Caseinate and Alginate/Whey proteins. Higher hue angle and lower chroma values were observed for all the beads with respect to the pure extract, indicating a reduction of the yellow/brown color. DSC highlighted higher thermal stability for the microbeads in comparison to the original ingredients, showing also new thermal transitions related to bonds formation between polymers and OLE.

Indexed as

Alginate beadsDifferential scanning calorimetryEncapsulationMicrostructureOlive leaves polyphenols

Identifiers

PMID34661168
PMCPMC8503818
OpenAlexW3206588940

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.