Evidence map›Paper›PMID 34661153›Full record

ArticleBlood cancer discovery2021

MYC and TFEB Control DNA Methylation and Differentiation in AML.

Xiaoying Wu, Robert N Eisenman

Open access · greenAbstract readComment
In one paragraph

Article in Blood cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Lysosomal biogenesis and function in osteoclasts: a comprehensive review.Frontiers in cell and developmental biology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaoying WuBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Robert N EisenmanBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. eisenman@fredhutch.org.ORCID https://orcid.org/0000-0002-0274-9846
Fred Hutch Cancer Center · US

Funding

The MYC Transcription Factor Network and the Path to CancerR35CA231989 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 2018 to 2024
$6.3M
NCI NIH HHS R35 CA231989
6 · The paper itself

Abstract

Although the MYC transcription factor has been consistently implicated in acute myeloid leukemia (AML), its gene targets and precise role in leukemogenesis remain unknown. In this issue of

Identifiers

PMID34661153
PMCPMC8447267
OpenAlexW3123613324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.