ArticleFunction (Oxford, England)2021
Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.
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Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Article
- Nervonic acid and 15-epi-PGA1 mediate systemic mitochondrial dysfunction in AD dementia.GeroScience · 2026Article
- Integrative physiology of skeletal muscle for maintaining cognitive health.The Journal of physiology · 2026Review
- A blood based mitochondrial functional index biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease.Neurobiology of disease · 2025Article
- Absolute substrate oxidation rates are lower in older adults with amnestic mild cognitive impairment.Physiological reports · 2025Article
- APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model.Function (Oxford, England) · 2025Article
- Eight weeks of creatine monohydrate supplementation is associated with increased muscle strength and size in Alzheimer's disease: data from a single-arm pilot study.Frontiers in nutrition · 2025Article
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle.PLoS pathogens · 2024Article
- Non-transgenic guinea pig strains exhibit divergent age-related changes in hippocampal mitochondrial respiration.Acta physiologica (Oxford, England) · 2024Article
- Investigation of the shared biological mechanisms and common biomarker APTAF1 of sleep deprivation and mild cognitive impairment using integrated bioinformatics analysis.Frontiers in pharmacology · 2024Article
- Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer's Disease.Function (Oxford, England) · 2024Article
- Skeletal muscle proteome differs between youngFrontiers in aging neuroscience · 2024Article
- Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function.Aging brain · 2024Article
- Metabolism and exercise: the skeletal muscle clock takes centre stage.Nature reviews. Endocrinology · 2023Review
- Early-stage Alzheimer's disease: are skeletal muscle and exercise the key?Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Editorial: Systemic implications of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Jill K MorrisDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-5911-4190
Colin S McCoinDepartment of Molecular and Integrative Physiology and Internal Medicine-Division of Endocrinology and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA.
Kelly N FullerDepartment of Molecular and Integrative Physiology and Internal Medicine-Division of Endocrinology and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA.
Casey S JohnDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Heather M WilkinsDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Zachary D GreenDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Xiaowan WangDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Palash SharmaDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3016-7541
Jeffrey M BurnsDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Eric D VidoniDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Jonathan D MahnkenDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
Kartik ShankarPediatrics, Section of Nutrition, The University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Russell H SwerdlowUniversity of Kansas Alzheimer's Disease Center, Kansas City, KS, USA.
John P ThyfaultUniversity of Kansas Alzheimer's Disease Center, Kansas City, KS, USA.
University of Kansas · USUniversity of Kansas Medical Center · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John A Stanford · 2012 to 2026
$63.0MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MUsing Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5MUniversity of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BROOKS, WILLIAM M. · 2011 to 2020
$16.6MNRSA Training CoreTL1TR002368 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jennifer Lynn Goldman, NICOLE L NOLLEN · 2017 to 2026
$4.0MStatins: Mitochondrial Function and Aerobic CapacityR01AR071263 · NIAMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NEUFER, P DARRELL, THYFAULT, JOHN P · 2017 to 2021
$3.0MAcute exercise and the cerebral metabolic response in aging and Alzheimer's DiseaseR01AG062548 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MORRIS, JILL KATHLEEN · 2020 to 2024
$2.4MFeasibility of Improving Glycemia to Prevent Alzheimer's DiseaseR01AG081304 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Paige C Geiger, Jill Kathleen Morris · 2023 to 2026
$1.9MRelationship between Amyloid beta and BioenergeticsR00AG056600 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WILKINS, HEATHER M. · 2020 to 2022
$747kRelationship of Energetics and Cognitive Trajectory’R00AG050490 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MORRIS, JILL KATHLEEN · 2018 to 2020
$747kSkeletal muscle mitochondrial abnormalities in Alzheimer's DiseaseR21AG056062 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2017 to 2018
$421kDementia Risk and Dynamic Response to ExerciseR21AG061548 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VIDONI, ERIC DENNIS · 2019 to 2020
$383kNCATS NIH HHS TL1 TR002368NIAMS NIH HHS R01 AR071263NIA NIH HHS F30 AG076278NIA NIH HHS K99 AG056600NIA NIH HHS P30 AG035982NIA NIH HHS R00 AG050490NIA NIH HHS R00 AG056600NIA NIH HHS R01 AG062548NIA NIH HHS R01 AG081304NIA NIH HHS R21 AG056062NIA NIH HHS R21 AG061548NIDDK NIH HHS P30 DK048520NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM130423
Abstract
Alzheimer's Disease (ad) associates with insulin resistance and low aerobic capacity, suggestive of impaired skeletal muscle mitochondrial function. However, this has not been directly measured in AD. This study (
Indexed as
Alzheimer DiseaseCognitive DysfunctionAgedDonepezilHumansMitochondriaMuscle, SkeletalDonepezilAlzheimer's diseasedonepezilmild cognitive impairmentmitochondriarespirationRNA sequencingskeletal muscle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.