Evidence map›Paper›PMID 34661080›Full record

ArticleACS pharmacology & translational science2021

Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts.

Gongxin Wang, Chieh-Ju Lu, Andrew W Trafford, Xiaohui Tian, Hannali M Flores, Piotr Maj, Kevin Zhang, Yanhong Niu, Luxi Wang, Yimei Du and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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  6. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 3 countries.

Gongxin WangHenan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng 475000, China.
Chieh-Ju LuHenan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng 475000, China.
Andrew W TraffordUnit of Cardiac Physiology, Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester M13 9PL, U.K.
Xiaohui TianDepartment of Pharmacy, Huaihe Hospital and College of Medicine, Henan University, Kaifeng 475000, China.
Hannali M FloresBiological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, U.K.
Piotr MajDepartment of Pharmacology, University of Oxford, Oxford OX1 2JD, U.K.
Kevin ZhangSchool of Medicine, Imperial College of London, London SW7 2AZ, U.K.
Yanhong NiuFuwai Central China Cardiovascular Hospital, Zhengzhou 450003, China.
Luxi WangHenan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng 475000, China.
Yimei DuDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xinying JiDepartment of Pharmacy, Huaihe Hospital and College of Medicine, Henan University, Kaifeng 475000, China.
Yanfang XuDepartment of Pharmacology, Hebei Medical University, Shijiazhuang City 050017, China.
Lin WuDepartment of Cardiology, Peking University First Hospital, Beijing 100034, China.
Dan LiDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 2JD, U.K.
Neil HerringDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 2JD, U.K.
David PatersonDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 2JD, U.K.
Christopher L-H HuangPhysiological Laboratory and Department of Biochemistry, University of Cambridge, Cambridge CB2 3EG, U.K.ORCID https://orcid.org/0000-0001-9553-6112
Henggui ZhangBiological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, U.K.
Ming LeiDepartment of Pharmacology, University of Oxford, Oxford OX1 2JD, U.K.
Guoliang HaoHenan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng 475000, China.
University of Oxford · GBHenan University Huaihe Hospital and Huaihe Clinical Institute · CNSouthwest Medical University · CNUniversity of Manchester · GBHebei Medical University · CNImperial College London · GBManchester Academic Health Science Centre · GBPeking University · CNUnion Hospital · CNZhengzhou Central Hospital · CN

Funding

British Heart Foundation FS/12/57/29717British Heart Foundation FS/17/52/33113British Heart Foundation FS/SCRF/20/32005British Heart Foundation PG/14/79/31102British Heart Foundation PG/14/80/31106British Heart Foundation PG/15/12/31280British Heart Foundation PG/16/67/32340British Heart Foundation PG/21/10512British Heart Foundation RG/17/14/33085
6 · The paper itself

Abstract

Hydroxychloroquine (HCQ), clinically established in antimalarial and autoimmune therapy, recently raised cardiac arrhythmogenic concerns when used alone or with azithromycin (HCQ+AZM) in Covid-19. We report complementary, experimental, studies of its electrophysiological effects. In patch clamped HEK293 cells expressing human cardiac ion channels, HCQ inhibited I

Identifiers

PMID34661080
PMCPMC8506600
OpenAlexW3196962209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.