Evidence map›Paper›PMID 34661078›Full record

ArticleACS pharmacology & translational science2021

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.

Alan Hegron, Eunna Huh, Xavier Deupi, Badr Sokrat, Wenwen Gao, Christian Le Gouill, Mickaël Canouil, Mathilde Boissel, Guillaume Charpentier, Ronan Roussel and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Why Are We Still Cloning Melatonin Receptors? A Commentary.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 5 countries.

Alan HegronUniversité de Paris, Institut Cochin, CNRS, INSERM, F-75014 Paris, France.
Eunna HuhDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030, United States of America.
Xavier DeupiLaboratory of Biomolecular Research, Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland.ORCID https://orcid.org/0000-0003-4572-9316
Badr SokratDepartment of Biochemistry and Molecular Medicine, University de Montréal, Montreal, Quebec, H3T 1J4 Canada.
Wenwen GaoUniversité de Paris, Institut Cochin, CNRS, INSERM, F-75014 Paris, France.
Christian Le GouillInstitute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, H3T 1J4 Canada.
Mickaël CanouilInserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, 59000, France.
Mathilde BoisselInserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, 59000, France.
Guillaume CharpentierCentre d'Étude et de Recherche pour l'Intensification du Traitement du Diabète, 91000, Evry, France.
Ronan RousselDepartment of Diabetology Endocrinology Nutrition, Hôpital Bichat, DHU FIRE, Assistance Publique Hôpitaux de Paris, 75004 Paris, France.
Beverley BalkauInserm U1018, Center for Research in Epidemiology and Population Health, 94805 Villejuif, France.
Philippe FroguelInserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, 59000, France.
Bianca PlouffeDepartment of Biochemistry and Molecular Medicine, University de Montréal, Montreal, Quebec, H3T 1J4 Canada.ORCID https://orcid.org/0000-0002-8321-0796
Amélie BonnefondInserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, 59000, France.
Olivier LichtargeDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030, United States of America.
Ralf JockersUniversité de Paris, Institut Cochin, CNRS, INSERM, F-75014 Paris, France.ORCID https://orcid.org/0000-0002-4354-1750
Michel BouvierDepartment of Biochemistry and Molecular Medicine, University de Montréal, Montreal, Quebec, H3T 1J4 Canada.ORCID https://orcid.org/0000-0003-1128-0100
Centre National de la Recherche Scientifique · FRInstitute for Research in Immunology and Cancer · CABaylor College of Medicine · USInserm · FRCentre d'Etudes et de Recherches pour l'Intensification du Traitement du Diabète · FRPaul Scherrer Institute · CH

Funding

Functional Determinnats in G Protein-coupled ReceptorsR01GM066099 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LICHTARGE, OLIVIER · 2003 to 2022
$7.5M
NIGMS NIH HHS R01 GM066099Wellcome Trust
6 · The paper itself

Abstract

Melatonin is a hormone mainly produced by the pineal gland and MT

Identifiers

PMID34661078
PMCPMC8507577
OpenAlexW3197717323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.